Rheumatological Manifestations in HIV-Positive Patients: A Single-Center Study
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ORIGINAL RESEARCH
Rheumatological Manifestations in HIV-Positive Patients: A Single-Center Study Renu Saigal
. Avik Chakraborty . Ram Narayan Yadav .
Laxmi Kant Goyal
Received: July 23, 2020 / Published online: August 24, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Rheumatological manifestations (RM) are very common in human immunodeficiency virus (HIV)-infected patients. The aim of this study was to determine the clinical spectrum of musculoskeletal involvement and relationship with the Centers for Disease Control and Prevention (CDC) stage and CD4? cells and other factors. Methods: A cross-sectional study was conducted involving 75 patients of over 18 years of either sex with confirmed HIV status attending a tertiary care hospital in north India in one calendar year. Baseline demographic details, relevant history including duration of Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12789584. R. Saigal Department of Medicine, JNU IMSRC Medical College, Jaipur, India A. Chakraborty Department of Medicine, TMC and Dr. BRAM Teaching Hospital, Hapania, Agartala, India R. N. Yadav Department of Medicine, SMS Medical College, Jaipur, Rajasthan, India L. K. Goyal (&) Geriatric Medicine, SMS Medical College, Jaipur, Rajasthan, India e-mail: [email protected]
combination antiretroviral therapy (cART), RM, joints involved, CD4 cell count, and biochemical parameters were evaluated. Results: Of 75 patients, 54 were male and 21 were female (mean age 33.15 ± 5.00 years, range 21–48 years). Most common RM was arthralgia (26.67%), followed by myalgia (18.67%), and arthritis (13.33%). Keratoderma blennorrhagicum (1.33%), tendo-achilles tendinitis (2.67%), and plantar fasciitis (2.67%) were other manifestations. Spondyloarthritis (SpA) was seen in 8% patients (undifferentiated SpA 4%, reactive arthritis 2.67%, psoriatic arthritis 1.67%). HIVassociated arthritis was seen in 2.67% while septic arthritis, rheumatoid arthritis, vasculitis, and diffuse infiltrative lymphocytic syndrome were seen in one patient (1.33%) each. The mean duration of disease in patients with RM was significantly less than patients without RM (p \ 0.01). The erythrocyte sedimentation rate in patients with RM was significantly higher than in patients without RM (p \ 0.05). Mean CD4 ? cells were also significantly lower in patients with RM as compared to patients without RM (p \ 0.05). Significantly fewer patients on cART had RM in comparison to patients not on cART (p \ 0.001). Of 35 patients with RM, 25 were in CDC stage IV. Conclusion: RM are common in HIV-infected patients. HIV arthralgia, myalgia, and undifferentiated SpA are the common manifestations. RM were associated with low CD4 counts. Most of the cases with RM were in CDC stage IV.
Adv Ther (2020) 37:4336–4345
Keywords: AIDS; Arthralgia; HIV; Rheumatological manifestations; Rheumatology Key Summary Points Human immunodeficiency virus (HIV) infection is common in India. Rheumatological manifestations (RM) are very common in HIV-infecte
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