Right ventricular function and dimensions in type 2 diabetes mellitus
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Right ventricular function and dimensions in type 2 diabetes mellitus Ralph Widya1,2, RW Van Der Meer1, Johannes W Smit2, Luuk Rijzewijk3, Michaela Diamant3, Jeroen J Bax4, Albert de Roos1, Hildo J Lamb1* From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Right ventricular (RV) function has proven to be of importance for patient risk stratification in heart failure and is associated with sudden death and exercise limitation. RV dysfunction might play an important role in diabetic cardiomyopathy. We therefore assessed RV function and volumes using MRI in patients with otherwise uncomplicated type 2 diabetes mellitus (T2DM), and compared RV parameters with those of the left ventricle (LV). Methods Steady-state free precession sequences were used to assess RV dimensions in 78 uncomplicated T2DM patients and 28 healthy subjects within the same range of age. Furthermore, flow velocity mappings across the pulmonary valve and tricuspid valve were used to assess RV outflow and diastolic filling patterns respectively. Results RV end-diastolic volume was significantly decreased in patients compared to healthy subjects, also after adjustment for BMI and pulse pressure (177 ± 28 ml vs. 197 ± 47 ml, P
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