Risk of ovarian cancer after assisted reproductive technology?
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Risk of ovarian cancer after assisted reproductive technology? Although there appears to be an increased long-term risk of ovarian cancer after assisted reproductive technology (ART) compared with the general population in the Netherlands, there is no increase in the risk compared with similarly-aged subfertile women not treated with ART. These were the findings of a study published in the Journal of the National Cancer Institute. This nationwide study used data from the Netherlands Cancer Registry and the Dutch Pathology Registry to evaluate the risk of invasive ovarian cancer and borderline ovarian tumours in 30 625 women who received ART including ovarian stimulation therapy between 1983 and 2000, compared with 9988 subfertile women who did not receive ART, and women in the general population in the Netherlands. Over a median follow-up duration of 24 years, 158 cases of invasive ovarian cancer and 100 cases of borderline ovarian tumours were reported in the cohorts of women who received ART or no ART. The risk of ovarian cancer was increased in women who received ART versus the general population (standardised incidence ratio [SIR] 1.43; 95% CI 1.18, 1.71) but not compared with subfertile women who did not receive ART (ageand parity-adjusted hazard ratio [aHR] 1.02; 95% CI 0.70, 1.50). The risk of ovarian cancer was lower with higher parity and in women who had a greater number of ART cycles resulting in childbirth (p=0.001 for trend). There was no association between ovarian hyperstimulation syndrome and ovarian cancer (HR 1.40; 95% CI 0.52. 3.81). The risk of borderline ovarian tumours was increased in women who received ART compared with both the general population (SIR 2.20; 95% CI 1.66, 2.86) and subfertile women who did not receive ART (aHR 1.84; 95% CI 1.08, 3.14). "ART-treated women do not have an increased risk of ovarian cancer compared with subfertile women not treated with ART. The higher risk of ovarian cancer compared with the general population is likely due to the higher prevalence of nulliparity in ART-treated women," the authors concluded. "Although lack of a dose-response relationship with ARTtreatment cycles does not support a causal association, more research is warranted to examine the role of ART in the etiology of borderline ovarian tumors," they added. Spaan M, et al. Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology Journal of the National Cancer Institute : 17 Nov 2020. 803520159 Available from: URL: https://doi.org/10.1093/jnci/djaa163
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Reactions 5 Dec 2020 No. 1833
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