RNA Metabolism in Trypanosomes
Trypanosomes are unicellular protozoa of ancient evolutionary origin that are responsible for several tropical diseases, such as African sleeping sickness. Over the last few decades, research in trypanosome biology has revealed many unique and fascinating
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Volume 28
Series Editor Janusz M. Bujnicki International Institute of Molecular and Cell Biology Laboratory of Bioinformatics and Protein Engineering Trojdena 4 02-109 Warsaw Poland
For further volumes: http://www.springer.com/series/881
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Albrecht Bindereif Editor
RNA Metabolism in Trypanosomes
Editor Albrecht Bindereif Department of Biology and Chemistry Justus Liebig University of Giessen Giessen Germany
ISSN 0933-1891 ISSN 1869-2486 (electronic) ISBN 978-3-642-28686-5 ISBN 978-3-642-28687-2 (eBook) DOI 10.1007/978-3-642-28687-2 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012940659 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
RNA Polymerases and Transcription Factors of Trypanosomes . . . Arthur G€ unzl
2
SL RNA Biogenesis in Kinetoplastids: A Long and Winding Road . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nancy R. Sturm, Jesse R. Zamudio, and David A. Campbell
29
Pre-mRNA Splicing in Trypanosoma brucei: Factors, Mechanisms, and Regulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Christian Preußer, Nicolas Jae´, Arthur G€ unzl, and Albrecht Bindereif
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mRNA Turnover in Tr
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