RNA Metabolism in Neurodegenerative Diseases
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, w
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Rita Sattler · Christopher J. Donnelly Editors
RNA Metabolism in Neurodegenerative Diseases
Advances in Neurobiology Volume 20
Series Editor Arne Schousboe
More information about this series at http://www.springer.com/series/8787
Rita Sattler • Christopher J. Donnelly Editors
RNA Metabolism in Neurodegenerative Diseases
Editors Rita Sattler Department of Neurobiology and Neurology Dignityhealth St. Joseph’s Hospital Barrow Neurological Institute Phoenix, AZ, USA
Christopher J. Donnelly Department of Neurobiology University of Pittsburgh Pittsburgh, PA, USA Live Like Lou Center for ALS Research University of Pittsburgh Brain Institute Pittsburgh, PA, USA
ISSN 2190-5215 ISSN 2190-5223 (electronic) Advances in Neurobiology ISBN 978-3-319-89688-5 ISBN 978-3-319-89689-2 (eBook) https://doi.org/10.1007/978-3-319-89689-2 Library of Congress Control Number: 2018943624 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Neurodegenerative diseases are rapidly increasing in prevalence in the growing population of the elderly worldwide. With this comes an increased financial and social burden to care for the affected individuals. There are no effective treatments for these diseases and the mechanistic underpinnings of these progressive and often fatal disorders remain unclear. This emphasizes the urge to better understand the underlying disease mechanisms, which will then allow for the development of new and more effective treatments. RNA metabolism denotes a variety of distinct processes RNA undergoes to promote cellular health and function. It has beco
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