SBDTC Derived Schiff Base Metal Complexation: Synthesis, Physicochemical, and Spectral Studies with Antibacterial Activi
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BDTC Derived Schiff Base Metal Complexation: Synthesis, Physicochemical, and Spectral Studies with Antibacterial Activity N. A. Bitua, S. Hossainb, A. Kadera, M. S. Islama, M. M. Haquea, F. Hossena, A. Asrafa, and Kudrat-E-Zahana,* a Department b Department
of Chemistry, University of Rajshahi, Rajshahi, 6205 Bangladesh of Chemistry, Begum Rokeya University, Rangpur, 5400 Bangladesh *e-mail: [email protected]
Received May 5, 2020; revised June 28, 2020; accepted August 6, 2020
Abstract—A Schiff base ligand derived from condensation of S-benzyldithiocarbazate (SBDTC) and salicylaldehyde, and its U(VI), Th(IV) and Zr(IV) complexes have been synthesized. The compounds are characterized by elemental analysis, molar conductance, magnetic moments, UV-Vis, FT-IR and 1H NMR spectra. The Schiff base ligand coordinates via azomethine nitrogen, thiol sulfur and/or the phenolic OH group, and acts as bidentate in case of U(VI) and Zr(IV) ions and tridentate with Th(IV) ion. The U(VI) and Th(IV) complexes are 1 : 2 electrolytes whereas Zr(IV) complex is non-electrolytic. All the compounds have been tested for their antibacterial activity against four pathogenic bacteria, two Gram-negative Escherichia coli and Shigella dysenteriae and two Gram-positive Staphylococcus aureus and Bacillus subtilis using Kanamycin (K-30) as a standard. The U(VI) and Th(IV) complexes exhibit stronger antibacterial activity than the Zr(IV) complex against all tested organisms. Keywords: Schiff base, SBDTC, heterocyclic amine, ESI-MS, antibacterial activity
DOI: 10.1134/S1070363220080228 In this study we present the synthesis, characterization and antimicrobial activity of U(VI), Th(IV), and Zr(IV) metal complexes containing heterocyclic amines and Schiff base ligand derived from the condensation of salicylaldehyde and S-benzyldithiocarbazate (SBDTC). EXPERIMENTAL All reagents used were analytically or chemically pure. Solvents were purified and dried according to the standard procedures. The melting points were recorded on an electro thermal melting point apparatus model no. AZ6512. Conductivity of 1.0×10–3 mol/dm3 solutions of the complexes in DMSO was measured at 30°C on a WPA CM 35 conductivity meter and a dip-cell with platinized electrodes. A Sherwood Scientific Magnetic Susceptibility Balance was used to measure the magnetic moment values. IR spectra were recorded for KBr disc on a SIMADZU FTIR-8400 spectrophotometer. UV-Vis spectra were recorded on a SHIMUDZU Spectrophotometer (Model UV-1800). 1H NMR spectra were measured on a Bruker 400, Ultra Shield TM spectrometer using CDCl3 as a solvent. ESI-MS spectra were measured on an Agilent Technologies MSD SL Trap mass spectrometer with
ESI source coupled with an 1100 Series HPLC system. Elemental analysis was carried out on a LECO (CHNS932) elemental analyzer. S-Benzyldithiocarbzate (SBDTC) was synthesized according to the method developed by Akbar Ali and Tarafder [1] as a gray solid, yield 78%, mp 126°C. Molar conductance (Ω–1 cm2 mol–1): 9.80. IR spectrum, ν, cm–1: 951 (C–S), 1051 (C=S), 3
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