Sensitivity Enhancement of Ag-ITO-TMDCs-Graphene Nanostructure Based on Surface Plasmon Resonance Biosensors
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Sensitivity Enhancement of Ag-ITO-TMDCs-Graphene Nanostructure Based on Surface Plasmon Resonance Biosensors Lei Han 1 & Zhenxing Chen 1 & Tianye Huang 1
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Huafeng Ding 1 & Chuan Wu 1
Received: 23 August 2019 / Accepted: 3 November 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract The novel configuration of surface plasmon resonance (SPR) based on Ag-indium tin oxide (ITO)-transition metal dichalcogenides (TMDCs)-graphene hybrid structures is proposed for highly sensitivity biosensor. When the WS2 and graphene are 3 layers and monolayer, respectively, the highest angular sensitivity up to 213.2°/RIU is obtained. Moreover, sensing media with different refractive indices can be detected by SPR biosensor. The phase sensitivity of 3.6 × 106 deg/RIU is obtained when the MoS2 and graphene are 3 layers and 4 layers, respectively. The highest phase sensitivity of the proposed SPR biosensor is about 2.79 times the Ag-ITO-MoS2-graphene structure and 4.16 times the Ag-ITO hybrid structure. The SPR biosensor has the advantages of high phase sensitivity, reusability, and reproducibility which make the sensor have the potential application prospects in medical diagnosis, environmental, and biochemical detection. Keyword Surface plasmon resonance . Indium tin oxide . Transition metal dichalcogenides . Graphene . Sensitivity
Introduction Surface plasmon resonance (SPR) biosensor can realize labelfree, real-time, high sensitivity, quantitative, and dynamic monitoring of the interaction between multiple biological molecules [1–4]. In recent years, the applications of SPR sensing technology in food safety detection, environmental monitoring, and medical diagnosis have developed rapidly [5–8]. In order to improve the performance of SPR, many researchers have studied new materials [9, 10], incident light in different wavelength [11, 12], and optimized the structure [13, 14]. It is known that the metal film plays an important role in SPR biosensor. The refractive index of metal surface directly affects the performance of SPR. A novel human IgG detection method based on Au/Ag alloy nanocomposites to amplify SPR response is proposed by Wang [15]. Li et al. proposed a new method for measuring the thickness of metal thin films by SPR phase detection [16]. A bimetallic SPR biosensor with high sensitivity based on periodic multilayer waveguide is proposed by Srivastava [17]. Wang et al. showed that with the increase of sensitivity of SPR biosensor, the resonance * Tianye Huang [email protected] 1
School of Mechanical Engineering and Electronic Information, China University of Geosciences (Wuhan), Wuhan 430074, China
wavelength of the biosensor based on Ag/Au film could move to a longer wavelength [18]. An Au-MgF2 plasma waveguide resonant sensor with simple structure is reported by Zhou [19]. Such sensor is insensitive to film coating deviation. Huang et al. proposed a phase-sensitive SPR sensor for wide dynamic range detection [20]. Transparent conductive indium tin oxide (ITO) is a relatively new t
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