Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressiv
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Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis Nejat Nizam,1 Pınar Gümüş,1 Jari Pitkänen,2 Taina Tervahartiala,2 Timo Sorsa,2,3 and Nurcan Buduneli1,4
Abstract—Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whole-mouth clinical periodontal measurements were recorded. Salivary, serum concentrations of MMP-8, MPO, TIMP-1, and NE were determined by immunofluorometric assay or ELISA in 18 patients with GCP, 23 patients with GAgP, 18 individuals with healthy periodontium. Patients in the GAgP group were younger than the other groups (p
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