Signal Transduction in the Cardiovascular System in Health and Disease
Signal Transduction in Cardiovascular System in Health and Disease Madhu B. Anand- Srivastava and Ashok K. Srivastava This book has addressed the contributions of several key signal transduction pathways which are central to our understanding of cardiovas
- PDF / 5,162,135 Bytes
- 426 Pages / 439.094 x 666.252 pts Page_size
- 54 Downloads / 227 Views
For other titles published in this series, go to http://www.springer.com/7064
Ashok K. Srivastava • Madhu B. Anand-Srivastava Editors
Signal Transduction in the Cardiovascular System in Health and Disease
123
Editors: Ashok K. Srivastava Department of Medicine University of Montreal and Research Centre of the Centre Hospitalier de l’ Universite de Montreal Montreal, PQ, H1W 4A4 Canada
ISBN 978-0-387-09551-6
Madhu B. Anand-Srivastava Department of Physiology Faculty of Medicine University of Montreal Montreal, PQ, H3C3J7 Canada
e-ISBN 978-0-387-09552-3
Library of Congress Control Number: 2008931349 c 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Cover illustration: Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com
Preface
In recent years, there has been a surge of interest in studies related to the role of a variety of signaling pathways in the control of cardiovascular physiology. Evidence has also accumulated to suggest that an aberration in the signal transduction pathways contributes to the pathophysiology of cardiovascular disease. Several components of the signaling pathways have been identified as potential targets for the development of new therapies of cardiovascular disease. Therefore, this volume has been compiled to highlight the contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This volume has been divided into five sections dealing with five key signaling pathways regulating different aspects of cardiovascular physiology. The first section describes the role of G-protein-coupled receptor (GPCR) signaling in cardiovascular functions. In this section, Anand-Srivastava has elegantly summarized studies showing that the expression levels of various G-proteins as well as responsiveness of adenylyl cyclase systems to various stimuli such as β-adrenergic receptor (βAR) agonist and vasoactive peptides are defective in various models of hypertension, congestive heart failure (CHF), cardiac hypertrophy, and other diseases. Dent et al. have highlighted studies showing how the alterations in different components of the βAR signaling system contribute to CHF and suggest that βAR blockade could be used as a strategy to treat CHF. Continu
Data Loading...
