Signaling Pathways in Liver Diseases
Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhot
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Signaling Pathways in Liver Diseases
1
Signaling Pathways in
Second Edition
d Ed.
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Signaling Pathways in Liver Diseases
Jean-Francois Dufour Pierre-Alain Clavien (Eds.)
Signaling Pathways in Liver Diseases Second edition
Prof. Jean-François Dufour University of Bern Institute of Clinical Pharmacology and Visceral Research Murtenstrasse 35 3010 Bern Switzerland [email protected]
Prof. Dr. Pierre-Alain Clavien Swiss HPB (Hepato-Pancreatico Biliary) Center University Hospital of Zurich Department of Visceral and Transplant Surgery Rämistrasse 100 8091 Zurich Switzerland [email protected]
ISBN: 978-3-642-00149-9 e-ISBN: 978-3-642-00150-5 DOI: 10.1007/978-3-642-00150-5 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009931701 © Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudio Calamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Recent advances in diagnostic and therapeutic approaches to liver disease have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo complex curative treatment strategies is a challenge to liver surgeons and hepatologists, who need to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis, and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate research that leads to exchanges between the laboratory, the clinical ward, and the operating room. Such a comprehensive insight including molecular and cellular events will pave the way for improvement of pharmacological and surgi
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