Signaling Pathways in Squamous Cancer
Squamous epithelia form the essential lining surface of tissues in contact with the environment, including the skin, and mucosa of the oral cavity, pharynx, larynx, esophagus, respiratory and genital tracts, and several other specialized tissues. These ti
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Adam B. Glick Carter Van Waes ●
Editors
Signaling Pathways in Squamous Cancer
Editors Adam B. Glick, Ph.D. Associate Professor Center for Molecular Toxicology and Carcinogenesis Department of Veterinary and Biomedical Sciences The Pennsylvania State University and Department of Dermatology Penn State Milton S. Hershey Medical Center [email protected]
Carter Van Waes, M.D., Ph.D. Clinical Director and Chief, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, Senior Investigator, Radiation Oncology Branch, National Cancer Institute National Institutes of Health [email protected]
ISBN 978-1-4419-7202-6 e-ISBN 978-1-4419-7203-3 DOI 10.1007/978-1-4419-7203-3 Springer New York Dordrecht Heidelberg London Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Squamous epithelia form the lining surface of tissues in contact with the environment, including the skin, upper aerodigestive, respiratory and genital tracts, and several other specialized tissues. Cancers that form in squamous epithelia are among the most common human solid tumors due to increased exposure to environmental carcinogens such as ultraviolet light, tobacco smoke, and other genotoxic compounds, as well as infectious agents such as human papilloma virus. Late stage cancers of the upper aerodigestive tract, esophagus and cervix have high morbidity and there has been little improvement in survival. Thus there is compelling need to identify critical signaling pathways that regulate the development of squamous cancer and translate these findings into therapeutic targets to improve patient survival. In general, squamous epithelia are multilayered or stratified epithelia in which proliferation is confined to the basal layer in contact with the basement membrane, and squamous differentiation occurs as cells move away from the basal layer.
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