Silodosin improves functional consequences of lower urinary tract obstruction secondary to benign prostate hypertrophy,
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RESEARCH ARTICLE
Open Access
Silodosin improves functional consequences of lower urinary tract obstruction secondary to benign prostate hypertrophy, a proof of concept study in the spontaneously hypertensive rat supplemented with testosterone Rana Assaly1,2, Julie Faugeroux1,2, Miguel Laurin1,2, Sandrine Compagnie1,2, Laurent Alexandre1, François Giuliano1,2,3 and Delphine Behr-Roussel1,2*
Abstract Background: The main purpose of this study is to investigate the effect of silodosin on the urodynamic consequences in a previously established model of lower urinary tract symptoms associated with benign prostate hyperplasia, the spontaneously hypertensive rats (SHR) supplemented with testosterone. Methods: Three groups of animals (8-week-old; n = 10/group) were considered: Wistar Kyoto (control) rats (WKY), SHR supplemented with testosterone at 3 mg/kg/day and treated with either vehicle (SHR-T, n = 10) or silodosin at 0.1 mg/kg/day (SHR-T + silodosin, n = 10) by oral gavage for 6 weeks. Cystometry experiments were performed. The bladder was harvested, weighed and paraffin-embedded for morphometric analysis. The prostate was also harvested and weighed. Results: The number of animals included in the analysis were n = 10/10 for WKY and n = 7–8/10 for each SHR rats supplemented with testosterone group. SHR-T displayed a significant decrease in the intercontraction interval, infused volume and mean flow rate whereas the frequency of non-voiding contractions was increased. Silodosin improved the voiding behavior of SHR-T by significantly increasing the intercontraction interval, the infused volume and the mean flow rate and decreasing the number of non-voiding contractions. SHR-T displayed a significant increase in prostate and bladder weights and a 15% increase in the detrusor wall area compared to WKY. Conclusions: Chronic silodosin treatment relieved storage symptoms in SHR supplemented with testosterone and decreased the frequency of non-voiding detrusor contractions during the filling phase. Keywords: Benign prostatic hyperplasia, Lower urinary tract obstruction, Bladder function, Silodosin, Experimental cystometry, Spontaneously hypertensive rats
* Correspondence: [email protected] 1 Pelvipharm, Montigny-le-Bretonneux, France 2 Université Paris-Saclay, UVSQ, Inserm, END-ICAP, Versailles, France Full list of author information is available at the end of the article
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