Slingshot homolog-1 expression is a poor prognostic factor of pT1 bladder urothelial carcinoma after transurethral resec
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ORIGINAL ARTICLE
Slingshot homolog‑1 expression is a poor prognostic factor of pT1 bladder urothelial carcinoma after transurethral resection Qiang Luo1 · Yanxia Liu2 · Hu Zhao1 · Peng Guo1 · Qianwen Wang2 · Wenjun Li1 · Gang Li3 · Bin Wu1 Received: 11 October 2019 / Accepted: 10 January 2020 © The Author(s) 2020
Abstract Objective Slingshot homolog-1 (SSH-1) shows an important role in the occurrence and development in various tumors. While, the expression and prognostic implications of SSH-1 in bladder urothelial carcinoma (UC) remain unclear and thus were addressed in this study. Methods Immunohistochemistry (IHC) was performed on tissue microarrays composed of 624 bladder UC specimens after transurethral resection of bladder tumor (TUR-BT) to detect SSH-1 expression. The clinic-pathological features were compared between SSH-1( +) and SSH-1(−) subgroups. The Kaplan–Meier curve with log-rank test and univariate/multivariate Cox regression model with stepwise backward elimination methods were performed for survival analyses. Results In this study, 359 (57.53%) specimens were detected with SSH-1 expression. SSH-1 positivity was significantly associated with higher pathological grade (p = 0.020), lymphovascular invasion (p = 0.006), tumor recurrence (p
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