Standardized herbal extract PM014 alleviates fine dust-induced lung inflammation in mice
- PDF / 1,584,259 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 17 Downloads / 139 Views
(2020) 20:270
BMC Complementary Medicine and Therapies
RESEARCH ARTICLE
Open Access
Standardized herbal extract PM014 alleviates fine dust-induced lung inflammation in mice Ye-Seul Lee1†, Daeun Min2†, Seon-Young Park2, Junyoung Lee2 and Hyunsu Bae2*
Abstract Background: Fine dust penetrates deep into the human alveoli, and the fine dust accumulated in the bronchus and lungs can directly trigger various respiratory diseases. PM014 (HL301) is the herbal extract derived from the herbal medicine Chung-Sang-Bo-Ha-Tang which is used for the treatment of lung diseases. Methods: To evaluate the effect of PM014 on the lung inflammation induced by fine dust, this study investigated inflammatory responses in the lung upon pm10 exposure by examining the infiltration of inflammatory cell profiles from bronchial alveolar lavage fluid (BALF), lung histology, and production of pro-inflammatory cytokines measured by RT-PCR and ELISA. Results: PM014-treated mice exhibited reduced lung tissue damage and inflammatory cell infiltration. Bronchoalveolar lavage fluid (BALF) analysis showed significant decrease in the population of total cells, macrophages, eosinophils, and neutrophils in PM014-treated mice. PM014 treatment downregulated the proinflammatory cytokine expressions including IL-1b, IL-8, IL-6, TNF-alpha, IL-21 and IL-17. ELISA analysis also showed reduced production of IL-1b, IL-6 and IL-17 in PM014-treated mice. Conclusion: PM014 suppressed the pm10-induced inflammatory response in mice. This study shows that PM014 is a possible therapeutic agent for lung inflammation induced by fine dust. Keywords: pm10, Fine dust, PM014, Chung-sang-Bo-ha-tang, BALF
Background Fine dust, or Particulate Matter 10 (pm10), is defined as inhalable particles with a diameter of less than 10 μm according to the United States Environmental Protection Agency. These particles vary in size and shape and consist of hundreds of different chemicals. Some are emitted directly from sources such as construction sites, unpaved roads, chimneys, and fires. However, most form in the atmosphere as a result of complex reactions of chemicals * Correspondence: [email protected] † Ye-Seul Lee and Daeun Min contributed equally to this work. 2 Department of Physiology, College of Korean Medicine, Kyung Hee University, 26-6 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02453, Republic of Korea Full list of author information is available at the end of the article
such as sulfur dioxide, nitrogen oxides, lead, ozone, carbon monoxide, and pollutants emitted by power plants, industries, and automobiles. It is possible that particle size is linked to the potential for health problems, the biggest problem being that small particles less than 10 μm in diameter can get deep into the lungs and enter the bloodstream. Exposure to these particles can affect both the lungs and the heart. Numerous scientific studies show that particle contamination exposure is associated with a variety of problems such as exacerbation of asthma, decrease in lung function, airway irritation, coughing, a
Data Loading...
