Statistical Analysis of Designed Experiments
This book is the second English edition of my German textbook that was originally written parallel to my lecture “Design of Experiments” which was held at the University of Munich. It is thought to be a type of resource/reference book which contains stati
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Statistical Analysis of Designed Experiments Second Edition
With Contributions by Thomas Nittner
Helge Toutenburg Institut fu¨r Statistik Universita¨t Mu¨nchen Akademiestrasse 1 80799 Mu¨nchen Germany [email protected]
Editorial Board George Casella
Stephen Fienberg
Ingram Olkin
Department of Statistics University of Florida Gainesville, FL 32611-8545 USA
Department of Statistics Carnegie Mellon University Pittsburgh, PA 15213-3890 USA
Department of Statistics Stanford University Stanford, CA 94305 USA
Library of Congress Cataloging-in-Publication Data Toutenburg, Helge. Statistical analysis of designed experiments / Helge Toutenburg.—2nd ed. p. cm — (Springer texts in statistics) Includes bibliographical references and index. ISBN 0-387-98789-4 (alk. paper) 1. Experimental design. I. Title. II. Series. QA279 .T88 2002 519.5—dc21 2001058976 Printed on acid-free paper. © 2002 Springer-Verlag New York, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag New York, Inc., 175 Fifth Avenue, New York, NY 10010, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Production managed by Timothy Taylor; manufacturing supervised by Jacqui Ashri. files. Photocomposed copy prepared from the author’s Printed and bound by Sheridan Books, Inc., Ann Arbor, MI. Printed in the United States of America. 9 8 7 6 5 4 3 2 1 ISBN 0-387-98789-4
SPIN 10715322
Springer-Verlag New York Berlin Heidelberg A member of BertelsmannSpringer Science+Business Media GmbH
Preface
This book is the second English edition of my German textbook that was originally written parallel to my lecture “Design of Experiments” which was held at the University of Munich. It is thought to be a type of resource/reference book which contains statistical methods used by researchers in applied areas. Because of the diverse examples it could also be used in more advanced undergraduate courses, as a textbook. It is often called to our attention, by statisticians in the pharmaceutical industry, that there is a need for a summarizing and standardized representation of the design and analysis of experiments that includes the different aspects of classical theory for continuous response, and of modern procedures for a categorical and, especially, correlated response, as well as more complex designs as, for example, cross–over and repeated measures. Therefore the book is useful for non statisticians who may appreciate the versatility of methods and examples, and for statisticians who will also fin
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