Stealth Polymer-Coated Graphene Oxide Decorated Mesoporous Titania Nanoplatforms for In Vivo Chemo-Photodynamic Cancer T
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RESEARCH PAPER
Stealth Polymer- Coated Graphene Oxide Decorated M e s o p o r o u s T i t a n i a Na n o p l a t f o r m s for In Vivo Chemo-Photodynamic Cancer Therapy Milan Gautam 1 & Biki Gupta 1 & Zar Chi Soe 1 & Kishwor Poudel 1 & Srijan Maharjan 1 & Jee-Heon Jeong 1 & Han-Gon Choi 2 & Sae Kwang Ku 3 & Chul Soon Yong 1 & Jong Oh Kim 1 Received: 18 June 2020 / Accepted: 28 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
ABSTRACT Purpose The goal of this study was to develop chemotherapeutic drug-loaded photoactivable stealth polymer-coated silica based- mesoporous titania nanoplatforms for enhanced antitumor activity. Methods Both in vitro and in vivo models of solvothermal treated photoactivable nanoplatforms were evaluated for efficient chemo-photothermal activity. A versatile nanocomposite that combined silica based- mesoporous titania nanocarriers (SMTN) with the promising photoactivable agent, graphene oxide (G) modified with a stealth polymer (P) was fabricated to deliver chemotherapeutic agent, imatinib (I), (referred as SMTN@IG-P) for near-infrared (NIR)-triggered drug delivery and enhanced chemo-photothermal therapy. Results The fabricated S-MTN@IG-P nanoplatform showed higher drug loading (~20%) and increased drug release (~60%) in response to light in acidic condition (pH 5.0). As prepared nanoplatform significantly converted NIR light into thermal energy (43.2°C) to produce reactive oxygen species (ROS). The pronounced cytotoxic effect was seen in both colon cancer cells (HCT-116 and HT-29) that was mediated Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11095-020-02900-1) contains supplementary material, which is available to authorized users. * Chul Soon Yong [email protected] * Jong Oh Kim [email protected] 1
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea
2
College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, Republic of Korea
3
College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of Korea
through the chemotherapeutic effect of imatinib and the photothermal and ROS generation effects of graphene oxide. In vivo study also showed that S-MTN@IG-P could significantly accumulate into the tumor area and suppress the tumor growth under NIR irradiation without any biocompatibility issues. Conclusion Cumulatively, the above results showed promising effects of S-MTN@IG-P for effective chemophototherapy of colon cancer.
KEY WORDS Mesoporous titania . graphene oxide . photothermal therapy . stealth-coated . biocompatibility
INTRODUCTION Photothermal therapy (PTT) employs near-infrared (NIR) light-absorbing nanomaterials to produce thermal energy from optical energy, which leads to the ablation of cancer cells; it has received considerable attention in nanomedicine (1,2). PTT uses external laser irradiation with a modifiable dosage that permits precise targeting at the tumoral sit
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