Stem Cell Genetics for Biomedical Research Past, Present, and Future
This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disord
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Stem Cell Genetics for Biomedical Research Past, Present, and Future
Stem Cell Genetics for Biomedical Research
Raul Delgado-Morales Editor
Stem Cell Genetics for Biomedical Research Past, Present, and Future
Editor Raul Delgado-Morales Duran i Reynals Hospital Bellvitge Biomedical Research Institute (IDIBELL) Barcelona, Spain
ISBN 978-3-319-90694-2 ISBN 978-3-319-90695-9 (eBook) https://doi.org/10.1007/978-3-319-90695-9 Library of Congress Control Number: 2018945917 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I Stem Cells for Brain Disorders 1 Human-Induced Pluripotent Stem Cell-Derived Neurons to Model and Gain Insights into Alzheimer’s Disease Pathogenesis������������������� 3 Jessica E. Young and Raul Delgado-Morales 2 Modeling Schizophrenia with Human Stem Cells�������������������������������� 13 Juliana Minardi Nascimento, Veronica M. Saia-Cereda, Giuliana S. Zuccoli, Danielle Gouvêa-Junqueira, and Daniel Martins-de-Souza 3 Rett Syndrome and Stem Cell Research������������������������������������������������ 27 Keita Tsujimura and Kinichi Nakashima 4 Stem Cell Applications in Spinal Cord Injury: A Primer�������������������� 43 James Hong, Christopher E. Rodgers, and Michael G. Fehlings 5 Cell-Based Therapy for Retinal Degenerative Disease ������������������������ 73 Marco A. Zarbin 6 Past, Present and Future of Cell-Based Therapy in Progressive Multiple Sclerosis ������������������������������������������������������������������������������������ 87 Giulio Volpe, Joshua D. Bernstock, Luca Peruzzotti-Jametti
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