Stem Cells and Cancer
Significance of Stem Cells to Tumor Development Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human d
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Stem Cells and Cancer Edited by
REBECCA G. BAGLEY, MS Genzyme Corporation, Framingham, MA, USA
BEVERLY A. TEICHER, PhD Genzyme Corporation, Framingham, MA, USA
Editors Rebecca G. Bagley Genzyme Corporation Framingham, MA USA
Beverly A. Teicher Genzyme Corporation Framingham, MA USA
ISBN: 978-1-60327-932-1 e-ISBN: 978-1-60327-933-8 DOI: 10.1007/978-1-60327-933-8 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2008944031 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. Stem cell therapy is a promising approach to the treatment of many debilitating diseases to replace specific differentiated cells that have been lost or died. Although stem cells may provide therapeutic benefit under certain conditions, stem cells are often implicated in the initiation, progression, and therapeutic resistance of malignant disease. This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. “Stemness,” self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied toward defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are impl
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