Steroid Hormone Resistance Mechanisms and Clinical Aspects

This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, proge

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo NICHOLAS R. DI LUZIO, Tulane University School of Medicine EPHRAIM KATCHALSKI-KATZIR, The Weizmann Institute of Science DA VID KRITCHEVSKY, Wistar Institute ABEL LA1THA, Rockland Research Institute RODOLFO PAOLETTI, University of Milan

Recent Volumes in this Series Volume 189 COMPARISON OF TYPE I AND TYPE II DIABETES: Similarities and Dissimilarities in Etiology, Pathogenesis, and Complications Edited by Mladen Vranic, Charles H. Hollenberg, and George Steiner Volume 190 WERNER'S SYNDROME AND HUMAN AGING Edited by Darrell Salk, Yoshisada Fujiwara, and George M. Martin Volume 191 OXYGEN TRANSPORT TO TISSUE VII Edited by F. Kreuzer, S. M. Cain, Z. Turek, and T. K. Goldstick Volume 192 MECHANISMS OF STIMULUS-RESPONSE COUPLING IN PLATELETS Edited by 1. Westwick, M. F. Scully, D. E. Macintyre, and V. V. Kakkar Volume 193 METHODS IN PORPHYRIN PHOTOSENSITIZATION Edited by David Kessel Volume 194 MYOCARDIAL AND SKELETAL MUSCLE BIOENERGETICS Edited by Nachman Brautbar Volume 195A PURINE AND PYRIMIDINE METABOLISM IN MAN V, Part A: Clinical Aspects Including Molecular Genetics Edited by W. L. Nyhan, L. F. Thompson, and R. W. E. Watts Volume 195B PURINE AND PYRIMIDINE METABOLISM IN MAN V, Part B: Basic Science Aspects Edited by W. L. Nyhan, L. F. Thompson, and R. W. E. Watts Volume 196 STEROID HORMONE RESISTANCE: Mechanisms and Clinical Aspects Edited by George P. Chrousos, D. Lynn Loriaux, and Mortimer B. Lipsett A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

STEROID HORMONE RESISTANCE Nlechanisms and Clinical Aspects

Edited by

George P. Chrousos D. Lynn Loriaux and

Mortimer B. Lipsett National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland

PLENUM PRESS • NEW YORK AND LONDON

Library of Congress Cataloging in Publication Data Main entry under title: Steroid hormone resistance. (Advances in experimental medicine and biology; v. 196) Proceedings of a satellite symposium, sponsored by the National Institute of Child Health and Human Development, to the Seventh International Congress of Endocrinology, held June 28-30, 1984, in Bethesda, Md. Includes bibliographies and index. 1. Steroid hormones-Congresses. 2. Drug resistance-Congresses. 3. Steroid hormones -Receptors-Congresses. I. Chrousos, George P. II. Loriaux, D. Lynn. III. Lipsett, Mortimer B. IV. National Institut of Child Health and Human Development (U.S.) V. International Congress of Endocrinology (7th: 1984: Quebec, Quebec) VI. Series. 612'.4 85-23250 RC649.M378 1986

ISBN-13: 978-1-4684-5103-0 DOl: 10.1007/978-1-4684-5101-6

e-ISBN-13: 978-1-4684-5101-6

Proceedings of a Satellite Symposium, sponsored by the National Institute of Child Health and Human Development, National Institutes of Health, to the