Stimulating Effect of the Water-Soluble Fraction from Brown Algae Fucus vesiculosus Extract on Cell Proliferation in the
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ulating Effect of the Water-Soluble Fraction from Brown Algae Fucus vesiculosus Extract on Cell Proliferation in the Tissue Culture of Young and Old Rats N. I. Chalisovaa, b, *, G. A. Rizhakb, **, M. A. Zayitsevac, ***, M. L. Alexandrovac, A. A. Krasnovac, V. V. Khalamand, ****, and L. S. Kozinab aPavlov
Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034 Russia St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 197110 Russia c Institute of Toxicology of Federal Medical-Biological Agency, St. Petersburg, 192019 Russia dWhite Sea Biological Station, Zoological Institute, Russian Academy of Sciences, St. Petersburg, 199034 Russia *e-mail: [email protected] **e-mail: [email protected] ***e-mail: [email protected] ****e-mail: [email protected] b
Received February 11, 2019; revised June 16, 2019; accepted June 19, 2019
Abstract—The influence of the F-55 water-soluble fraction of brown algae extract Fucus vesiculosus on the development of organotypic tissue culture of various origins from three germ layers in young and old rats was studied. The F-55 preparation has a stimulating effect on the processes of cell proliferation in tissues of ecto-, ento- and mesodermal genesis (cerebral cortex, myocardium, spleen, and liver) by regulating the processes of cell proliferation and apoptosis. The revealed strengthening of regeneration processes in explants from both young and old rats under the influence of the F-55 preparation in ultra-low concentrations of 10–100 ng/mL can be used to produce new, medicinal, cytoprotective substances that allow the enhancement of cell regeneration in various tissues under pathological conditions, including those associated with age. Keywords: cytoprotective preparations, algae Fucus vesiculosus, organotypic tissue culture, aging DOI: 10.1134/S2079057020030054
INTRODUCTION The study of the homeostatic mechanisms is a high-priority area in modern biology and medicine. The maintenance of a stable internal environment at the cellular level is regulated by signals that are required to preserve the equilibrium between two key physiological processes—proliferation and programmed cell death (apoptosis) [2, 5, 6, 12]. Cytokines play a key role in the regulation of body homeostasis by controlling structural and functional aspects of cellular homeostasis [4, 9, 10, 13]. Nevertheless, the search for substances that exert a cytoprotective effect, including geroprotective activity, and enhance tissue regeneration remains an unresolved challenge in biology and clinical medicine. As a result, research on new drugs that exhibit enhanced cytoprotective effects in tissues of young and old organisms continues. The study of brown algae, including Fucus vesiculosus, may contribute significantly to the development of new pharmaceutical agents. Fucus vesiculosus extract is known to display antioxidant activity [11] due to the structural similarity between fucoxanthin, β-carotene,
and vitamin A, which explains its cytoprotective properties. However, the development o
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