Stroke Research in China over the Past Decade: Analysis of NSFC Funding
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REVIEW ARTICLE
Stroke Research in China over the Past Decade: Analysis of NSFC Funding Lijun Zhu 1 & Dongsheng He 2 & Lijuan Han 2 & Heqi Cao 1
Received: 3 May 2015 / Accepted: 6 May 2015 / Published online: 5 June 2015 # Springer Science+Business Media New York 2015
Abstract We analyzed the projects and published studies funded by NSFC (National Natural Science Foundation of China) in the field of stoke. Further more, we searched the published papers supported by NSFC in the last decade using the keywords of "stroke" or "cerebrovascular disease" and analyzed the results according to the topics associated with the mechanisms of ischemic brain injury, novel techniques and new drugs, medical imaging, translational medicine, and traditional Chinese medicine. Keywords NSFC . Stroke . Mechanisms and neuroprotection . Translational medicine More and more neuroscientists, neurologists, neurosurgeons, and neuroradiologists are focusing on stroke research. In China, the number of patients who died from stroke in China is three times more than that of coronary heart disease
Lijun Zhu and Dongsheng He contributed equally to this work. * Heqi Cao [email protected] Lijun Zhu [email protected] Dongsheng He [email protected] Lijuan Han [email protected] 1
Department of Health Sciences, National Natural Science Foundation of China, Beijing 100085, China
2
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
[1]. The main source of stroke research funding within the country has been the National Natural Science Foundation of China (NSFC). From 2004 to 2014, both the amount of funding for projects in cerebrovascular disease supported by NSFC and the number of projects funded have grown substantially. In 2004, 30 cerebrovascular disease projects were supported by NSFC, and the amount of funding was six million yuan. But in 2014, the number of projects reached 101 and the amount of funding increased to 54.3 million yuan. A total of 725 projects and 289.452 million yuan were contributed over the course of the decade. Many papers supported by NSFC have been published in the past 10 years. Over 1900 of them are related to stroke or cerebrovascular disease supported by NSFC in the last decade. A growing number of these studies have been published in the world’s high-level journals, such as Nature Medicine, Lancet, Circulation, Brain, Neurology, Journal of Neuroscience, Annals of Neurology, and Stroke. Mechanisms and neuroprotection are the most common topics of study. Many processes, such as the mitogenactivated protein kinase (MAPK) pathway, toll-like receptor 4 (TLR4) signaling, and DAPK1-p53 interactions, were found to be related to brain injury after stroke [2–4]. Inflammatory and immune responses have been proved to be important in pathologic process of stroke [5–9]. Interferon regulatory factor 9 (IRF9), CXCL12, and FasL mutation were found to play a key role in inflammatory and immune responses after stroke [8, 10, 11]. Some scientist
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