Structural investigation of group 10 metal complexes with thiosemicarbazone: crystal structure, mass spectrometry, Hirsh
- PDF / 1,578,613 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 37 Downloads / 182 Views
ORIGINAL RESEARCH
Structural investigation of group 10 metal complexes with thiosemicarbazone: crystal structure, mass spectrometry, Hirshfeld surface and in vitro antitumor activity Carolane M. Almeida 1 & João G. M. de Carvalho 2 & Mahmi Fujimori 3 & Eduardo L. França 3 & Adenilda C. Honorio-França 3 & Renato L. T. Parreira 4 & Renato P. Orenha 4 & Claudia C. Gatto 1 Received: 24 March 2020 / Accepted: 5 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The current work reports the synthesis and structural investigation of three novel complexes with 2-acetyl-pyridine-N(4)phenylthiosemicarbazone (HL1), [Ni(L1)Cl] (1), [Pd(L1)Cl] (2) and [Pt(L1)PPh3]Cl•2MeOH (3). The compounds were structurally characterized by means of single-crystal X-ray crystallography and spectroscopic techniques. All three complexes exhibit tetracoordinated metal centers in a square planar fashion with the thiosemicarbazone acting as a tridentate NNS-donor atoms. Intermolecular hydrogen bonds and π···π stacking interactions, building supramolecular assemblies in the complexes, were analyzed using the Hirshfeld surface. Mass spectrometry data showed the presence in solution of the characteristic fragmentation with the [M+H]+ molecular ion for all complexes. The thermochemical data, estimated by computational chemistry, allowed elucidate the relative intensity of the peaks present in the mass spectrum of the compounds investigated. The antitumor activity and selectivity of the free thiosemicarbazone ligand and their M(II) complexes (M = Ni, Pd, Pt) were evaluated against MCF-7, PBMC, and healthy cells. All compounds studied showed the death of cancer cells observing a great selectivity for the Ni(II) complex. Keywords Metal complexes . Thiosemicarbazone . Crystal structures . Cytotoxicity . Human cancer cell
Introduction Breast cancer is the cause of a large number of women’s deaths around the world nowadays. Although there is growing Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11224-020-01564-2) contains supplementary material, which is available to authorized users. * Claudia C. Gatto [email protected] 1
Laboratory of Inorganic Synthesis and Crystallography, Institute of Chemistry, University of Brasília, Campus Darcy Ribeiro, Brasília, DF 70904-970, Brazil
2
Chair for Inorganic and Metal-Organic Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany
3
Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças CEP 78600-000, Brazil
4
Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil
research on this topic, there are many challenges still to be overcome, mainly related to the development of therapy drugs [1, 2]. The reason for that is the absence of specific treatment for all stages of the disease [3]. The most conventional treatment is generally aggressive to the human organism and is connected to a decrease in the patients’ qua
Data Loading...
