Imaging Mass Spectrometry Protocols for Mass Microscopy
Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies ar
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Mitsutoshi Setou Editor
Imaging Mass Spectrometry Protocols for Mass Microscopy
Editor
Mitsutoshi Setou M.D., Ph.D. Professor and Chairman Molecular Imaging Frontier Research Center Department of Molecular Anatomy Hamamatsu University School of Medicine 1-20-1 Handayama, Higashi-ku, Hamamatsu Shizuoka 431-3192, Japan [email protected]
The cover illustration of a mass microscope prototype is by Kunio Okawara, the Japanese mechanical designer famous for his designs for the anime series Mobile Suit Gundam, and is inspired by the Shimadzu machine architecture as described by the editor, Mitsutoshi Setou. © Kunio Okawara 2010
This book is based on the Japanese original, Shitsuryo Kenbikyo Ho: Imaging Mass Spectrometry Jikken Protocol, M. Setou, editor; published by Springer Japan, 2008.
ISBN 978-4-431-09424-1 e-ISBN 978-4-431-09425-8 DOI 10.1007/978-4-431-09425-8 Springer Tokyo Berlin Heidelberg New York Library of Congress Control Number: 2009939108 © Springer 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Imaging mass spectrometry (IMS, also known as mass spectrometry imaging) is a technique to visualize the spatial distribution of, e.g., compounds, biomarkers, metabolites, peptides, or proteins by their molecular masses. Recently, research groups around the world have developed IMS, and pharmaceutical companies have started using IMS technology for purposes such as drug ADME (absorption, distribution, metabolism, excretion) analyses to study pharmacokinetics and the medical properties of drugs. This use of IMS technology will continue to expand in the areas of drug research and disease-related biomarker screening. Consequently, the number of researchers interested in the practical use of IMS is increasing both in academic and in industrial fields. Under these circumstances, there is a real need for practical knowledge and techniques for the application of IMS. This book is intended for beginners as well as for researchers who have relatively little experience in the field. Detailed practical protocols are covered, so readers will immediately be able to perform IMS. We hope this book lays the groundwork for future progress in IMS technique and ultimately makes a contribution to progress in human health. Mitsutoshi Setou
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Contents
Part I 1
IMS as an Historical Innovation .............................................................. Mitsutoshi Setou
Part II 2
Innovation of Imaging Mass
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