Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalenceph
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PAEDIATRIC NEURORADIOLOGY
Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly Tae Yeon Jeon 1 & Andrew V. Poliakov 2 & Seth D. Friedman 2 & Xiuhua L. Bozarth 3 & Edward J. Novotny 3 & Jason S. Hauptman 4 & Sung-Hoon Moon 5 & Dennis W. W. Shaw 2 Received: 21 April 2020 / Accepted: 5 July 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To investigate the gross white matter abnormalities in the structural brain MR imaging as well as white matter microstructural alterations using tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) in both affected and contralateral cerebral hemispheres of children with hemimegalencephaly (HMEG). Methods From 2003 to 2019, we retrospectively reviewed brain MR images in 20 children (11 boys, 2 days– 16.5 years) with HMEG, focusing on gross white matter abnormalities. DTI was evaluated in 12 patients (8 boys, 3 months–16.5 years) with HMEG and 12 age-, sex-, and magnetic field strength-matched control subjects. TBSS analysis was performed to analyze main white matter tracts. Regions of significant differences in fractional anisotropy (FA) were determined between HMEG and control subjects and between affected and contralateral hemispheres of HMEG. Results Gross white matter abnormalities were noted in both affected (n = 20, 100%) and contralateral hemisphere (n = 4, 20%) of HMEG. FA values were significantly decreased in both hemispheres of HMEG, compared with control subjects (P < 0.05). Contralateral hemispheres of HMEG showed regions with significantly decreased FA values compared with affected hemispheres (P < 0.05). Conclusions In addition to gross white matter abnormalities particularly evident in affected hemispheres, DTI analysis detected widespread microstructural alterations in both affected and contralateral hemispheres in HMEG suggesting HMEG may involve broader abnormalities in neuronal networks. Keywords Hemimegalencephaly . White matter . Magnetic resonance imaging . Diffusion tensor imaging . Tract-based spatial statistics
* Tae Yeon Jeon [email protected] 1
Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, Republic of Korea
2
Department of Radiology, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA
3
Department of Neurology, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA
4
Department of Neurological Surgery, Seattle Children’s Hospital, University of Washington, Seattle, WA, USA
5
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea
Abbreviations HMEG Hemimegalencephaly DTI Diffusion tensor imaging FA Fractional anisotropy ROI Region-of-interest TBSS Tract-based spatial statistics MNI Montreal Neurological Institute FSL FMRIB Software Library mTOR Mammalian target of rapamycin
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