Structural, thermal, spectral and sustainable drug release studies of deoxyfluorouridine tagged poly(d,l-Lactide)
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Structural, thermal, spectral and sustainable drug release studies of deoxyfluorouridine tagged poly(d,l‑Lactide) A. Thamizhlarasan1 · B. Meenarathi2 · V. Parthasarathy3 · A. Jancirani4 · R. Anbarasan5 Received: 15 July 2020 / Revised: 28 September 2020 / Accepted: 13 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The deoxyfluorouridine tagged poly(d,l-Lactide) was prepared by the ROP method using deoxyfluorouridine (DF) as an initiator and stannous octoate (SO) as a catalyst under N2 atmosphere at 160 °C for 2 h. ROP of d,l-Lactide was also achieved at various monomer to initiator [M/I] ratios whereas the ratio of monomer to catalyst [M/C] was kept at 1000. For polymer characterization, FT-IR, 1H-NMR, UV–visible, fluorescence emission spectra, SEM, GPC, DSC, TGA and POM were used. The FT-IR based RI[C=O/C–H] indicated a 0.23 order of ROP of d,l-Lactide. The increase in Tm of PLLA was observed while increasing the ratio of [M/I]. The GPC results declared the ring-opening activity of DF toward d,l-Lactide. The presence of microvoids made the PLLA as a suitable candidate for sustainable drug delivery applications. The release of DF from PLLA was examined to assess the drug release efficiency of the prepared polymer system at three different pH levels. Keywords PLLA · Deoxyfluorouridine · Synthesis · GPC · Sustainable drug release study
* R. Anbarasan [email protected] 1
Department of Plastic Technology, VSVN Polytechnique College, Virudhunagar 626 001, Tamil Nadu, India
2
Department of Polymer Technology, KCET, Madurai 625 701, Tamil Nadu, India
3
Department of Physics, Hindustan Institute of Technology and Science, Chennai 603 103, Tamil Nadu, India
4
Department of Chemistry, The American College, Madurai 625 002, Tamil Nadu, India
5
Department of Chemical Engineering, National Taiwan University, 10617 Taipei, Taiwan
13
Vol.:(0123456789)
Polymer Bulletin
Introduction Polymers play a vital role in the pharmaceutical field as a drug carrier material because of their less cytotoxicity, biocompatibility and the presence of microvoids in their internal structures. Among the biomedical polymers, poly(d,l-Lactide) (PLLA) is an important polymer owing to its biodegradability and biocompatibility. It can be prepared by the ROP technique via the coordination insertion mechanism. The preparation of PLLA can be carried out by using various initiator systems. Synthesis of a drug-loaded PLLA includes multistep reactions with the use of hazardous solvents during its synthesis via hydrogen bonding mechanism. Moreover, the conventional drug loading leads to the release of drug at a stretch when the pH or other experimental conditions were changed. This creates uneasy situation to the ill-health human beings. Hence, a sustainable drug release is necessary. In order to tackle the above mentioned problem, the present research work was made. The novelty of the present research work is synthesis of drug conjugated PLLA without the use of hazardous solvents for its synthes
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