Study of heating curves generated by magnetite nanoparticles aiming application in magnetic hyperthermia
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ORIGINAL PAPER
Study of heating curves generated by magnetite nanoparticles aiming application in magnetic hyperthermia F. A. S. da Silva1 · M. F. de Campos1 Received: 30 July 2019 / Revised: 4 May 2020 / Accepted: 14 May 2020 © Associação Brasileira de Engenharia Química 2020
Abstract Malignant tumors occur by uncontrolled multiplication of the body’s cells. Currently, a promising technique, called magnetic hyperthermia, has been intensively researched. The technique makes it possible to interrupt the growth of tumor cells by the localized application of heat from the magnetization/demagnetization of magnetic nanoparticles (the Joule effect). The amount of heat generated depends on the magnetic material and the characteristics of the external magnetic field. In this work, magnetite F e3O4 particles (core–shell layer type) were synthesized by the wet coprecipitation method and coated with a polymer blend of polyethylene glycol and polyvinylpyrrolidone (PEG/PVP). The nanoparticles were subjected to a magnetic field of intensity equal to 12 kA m−1 and frequency 202 kHz. Under these conditions, specific absorption rate (SAR) values between 15–48 W g−1 were obtained. The heating curves obtained were adjusted with a proposed mathematical model. The adjustments were satisfactory and showed a good correlation coefficient (at an averaged level of 0.99). In addition, hysteresis curves and FTIR spectra were obtained. Keywords Magnetic hyperthermia · Nanoparticles · Magnetite · Mathematical model List of symbols I Electric current, [A] f Frequency, [kHz] t Magnetic field exposure time, [min] ΔT Temperature variation in the hyperthermia assay, [°C] Abbreviations PEG Polyethylene glycol PVP Polyvinylpyrrolidone SAR Specific absorption rate MHF Magnetic fluid hyperthermia
Introduction Nanotechnology Nanotechnology involves the study of nature on a considerably reduced scale, looking for new properties and applications. The development of this area of knowledge * F. A. S. da Silva [email protected] 1
Universidade Federal Fluminense, Av. dos Trabalhadores, 420, Vila Santa Cecília, Volta Redonda, RJ, Brazil
significantly affects both biotechnology and medicine. The use of nanometer-scale materials, especially magnetic nanoparticles, is currently a hotly debated topic in the life sciences. Due to their adjustable size and their physical and chemical properties, magnetic nanoparticles have demonstrated a wide range of applications from medical diagnostics to specific treatments (Obre-Lópeza et al. 2013).
Magnetic nanoparticles Nanoparticles are perhaps the most promising nanomaterial in the health sciences today. When the particle size is reduced to a scale of 1–100 nm, the materials exhibit unique physical, chemical and biological properties (Indulekha et al. 2017). The diagnosis and treatment of cancer are among the most likely applications of magnetic nanoparticles. Research in this field involves the design, synthesis and characterization of a wide variety of unconventional nanoparticles and core–s
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