Study on the dynamic change law and correlation between CT imaging manifestations and cellular immunity of 2019 novel co
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ORIGINAL ARTICLE
Study on the dynamic change law and correlation between CT imaging manifestations and cellular immunity of 2019 novel coronavirus disease Minxia Yang1 · Haijia Mao1 · Lujiao Chen1 · Li Zhao1 · Sangying Lv1 · Yanan Huang1 · Bo Chen1 · Mingzhu Wei1 · Guanzuan Wu1 · Bingqian Zhang1 · Xuedong Sun2 · Guozhong Zhou3 · Minhui Li4 · Zhenhua Zhao1 Received: 22 March 2020 / Accepted: 31 May 2020 © Japan Radiological Society 2020
Abstract Purpose To explore the dynamic changes and correlation between CT imaging manifestations and cellular immunity of COVID-19. Materials and methods This retrospective review analyzed 23 patients with COVID-19, including 13 males and 10 females aged 27–70 years, with an average age of 48 years. Patients were divided into two groups: group A with 11 critical-severe patients, and group B with 12 common-mild patients. Clinical, laboratory, and radiological data were collected and analyzed. Results LYM, LYM (%), CD3+, CD4+, and CD8+ decreased, while NEU (%), CRP, and CT scores increased in all patients, WBC in group A increased. In group A, on day 10–12 after disease onset, CT scores and CRP reached the highest point, and day 13–15 LYM, LYM (%) reached the lowest but NEU (%) and WBC reached the highest, CD3+, CD4+ and CD8+ were at the lowest on day 10–15. In group B, on day 7–9, CT scores, NEU (%) and CRP reached the peak, but LYM, LYM (%), CD3+, CD4+ and CD8+ reached the lowest. In all patients, CT scores had a significantly negative correlation with CD3+, CD4+, CD8+, LYM (%), and LYM (p = 0.001, r = − 0.797; p = 0.008, r = − 0.698; p = 0.002, r = − 0.775; p
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