The Interface Between Innate and Acquired Immunity
All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobia
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M.B.A. Oldstone, La Jolla/California · S. Olsnes, Oslo M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California· H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
The Interface Between Innate and Acquired Immunity Edited by M.D. Cooper and H. Koprowski
With 15 Figures and 3 Tables
Springer
Professor Dr. MAx D. COOPER University of A1abama at Birmingham Howard Hughes Medical Institute Research Laboratories 378 Wallace Tumor Institute Birmingham, Alabama 35294, USA E-mail: [email protected] Professor Dr. HILARY KOPROWSKI Jefferson Medical College Department of Microbiology and Immunology Center for Neurobiology, Jefferson Alumni Hall 1020 Locust Street, Phi1adelphia, PA 19197-6799, USA E-mail: [email protected] Cover Illustration: The phylogenetic relationship betll'een the recently discovered Fc receptor homologs and classical Fc receptor family members is indicated by the colorcoded depiction of their extracellular Ig-like domains and a corresponding phylogenetic tree (Fig. 4 olDavis et al., this volume). Each domain is color-coded in a manner corre;ponding to its clustering pasit ion. The ClustalX program lI'as used for comparative analysis ol an all-against-all amina acid sequence alignment of the Iglike domains. The unrooted tree topology lI'as estimated using TreeCon. The branch values, representing percentage Bootstrap support after 500 replicates, indicate a high degree of confidence in the validity al the relationships.
ISSN 0070-2l7X ISBN 978-3-642-07682-4 ISBN 978-3-662-04700-2 (eBook) DOI 10.1007/978-3-662-04700-2 This work is subject to copyright. Ali rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions ofthe German Copyright Law ofSeptember 9, 1965, in its current version, and permis sion for use must always be obtained from Springer-Verlag. Violations are Iiable for prosecution under the German Copyright Law. http://www.springer.de
© Springer-Verlag Berlin Heidelberg 2002 Originally published by Springer-Verlag Berlin Heidelberg New York in 2002 Softcover reprint ofthe hardcover Ist edition 2002 Library ofCongress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant literature. Co
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