SUMOylation of the transcription factor NFATc1 leads to its subnuclear relocalization and IL2 repression by HDAC
- PDF / 63,256 Bytes
- 1 Pages / 610 x 792 pts Page_size
- 33 Downloads / 161 Views
BioMed Central
Open Access
Meeting abstract
SUMOylation of the transcription factor NFATc1 leads to its subnuclear relocalization and IL2 repression by HDAC A Nayak*1, J Glöckner-Pagel1, M Vaeth1, M Buttmann2, T Bopp3, E Schmitt3, E Serfling1 and F Berberich-Siebelt1 Address: 1Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany, 2Department of Neurology, University of Würzburg, Würzburg, Germany and 3Institute of Immunology, University Mainz, Mainz, Germany * Corresponding author
from 12th Joint Meeting of the Signal Transduction Society (STS). Signal Transduction: Receptors, Mediators and Genes Weimar, Germany. 29–31 October 2008 Published: 26 February 2009 Cell Communication and Signaling 2009, 7(Suppl 1):A7
doi:10.1186/1478-811X-7-S1-A7
12th Joint Meeting of the Signal Transduction Society (STS). Signal Transduction: Receptors, Mediators and Genes
Frank Entschladen, Karlheinz Friedrich, Ralf Hass and Ottmar Janssen Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.This abstract is available from: http://www.biosignaling.com/content/7/S1/A7 © 2009 Nayak et al; licensee BioMed Central Ltd.
The family of NFAT (Nuclear Factor of Activated T-cells) transcription factors plays an important role in cytokine gene regulation. In peripheral T-cells, NFATc1 and c2 are pre-dominantly expressed. Due to different promoter and polyA site usage as well as alternative splicing events, NFATc1 is synthesized in multiple isoforms. The highly inducible NF-ATc1/A contains a relatively short C-terminus whereas the longer, constitutively expressed isoform NFATc1/C spans an extra C-terminal peptide of 246 amino acids. Interestingly, this NFATc1/C-specific terminus can be highly sumoylated. Upon sumoylation, NFATc1/C – but not the unsumoylated NFATc1/A – translocates to Promyelocytic Leukemia-nuclear bodies (PMLnbs). This leads to interaction with HDACs followed by deacetylation of histones, which in turn induces transcriptionally inactive chromatin. As a consequence, expression of the NFATc1 target gene interleukin-2 is suppressed. These findings demonstrate that the modification by SUMO converts NFATc1 from an activator to a site-specific transcriptional repressor, revealing a novel regulatory mechanism for NFATc1 function.
Page 1 of 1 (page number not for citation purposes)
Data Loading...
