Sunitinib
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Left ventricular dysfunction: case report A 51-year-old hypertensive woman with a history of preeclampsia developed left ventricular dysfunction during treatment with sunitinib for metastatic renal cancer. One month after a radical nephrectomy, the woman began receiving oral sunitinib 50 mg/day in cycles of 4 weeks on, 2 weeks off [duration of treatment not stated]. She developed severe dyspnoea, and her blood pressure became poorly controlled with her usual therapy [time to reaction onset not stated]. Investigations revealed ventricular repolarisation abnormalities, reduced left ventricular ejection fraction, mitral regurgitation, and increased troponin levels. Sunitinib was withdrawn and the dosage of her antihypertensive medication were increased. Her ejection fraction improved and heart failure symptoms regressed. Author comment: "Sunitinib cardiotoxicity may be aggravated in hypertensive patients with a history of preeclampsia". Gallucci G, et al. Sunitinib-induced left ventricular dysfunction in a hypertensive woman with a history of preeclampsia. A possible interaction between angiogenetic factors. Giornale Italiano di Cardiologia 12 (Suppl. 3): e105, No. 123, Dec 2011. Available from: URL: http://www.giornaledicardiologia.it [abstract] 803070597 Italy
0114-9954/10/1402-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 19 May 2012 No. 1402
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