Survival Analysis of Oral Squamous Cell Carcinoma Patients Attending Tertiary Care Centre of North India
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ORIGINAL ARTICLE
Survival Analysis of Oral Squamous Cell Carcinoma Patients Attending Tertiary Care Centre of North India Jaimanti Bakshi 1 & Navjot Kaur 1 & Harsimran Tiwana 1 & Roshan K. Verma 1 & Naresh K. Panda 1 & Sourabha Kumar Patro 1 Received: 23 May 2019 / Accepted: 19 August 2020 # Indian Association of Surgical Oncology 2020
Abstract The cumulative survival for all stages in oral squamous cell cancers (OSCC) in the world remains poor despite the advances in management; hence, we conducted this study to evaluate the survival outcomes. This is a retrospective review and analysis of treatment, follow-up and survival records of 249 OSCC patients treated in our department from April 2010 to April 2014. Telephonic interviews were conducted for survival details for some patients who had not reported. Survival analysis was done using the Kaplan-Meier analysis, comparisons were done using log-rank test and multivariate analysis was conducted using the Cox proportional hazard model to find different variables (site, age, sex, stage and treatment) affecting overall survival (OS)/ disease-free survival (DFS). Two-year and 5-year DFS for OSCC were observed to be 72.3% and 58.3% with mean survival of 63.17 months (95% CI: 58.342–68.002). Similarly, OS at 2 years and 5 years were 84.3% and 55.9% with mean survival of 65.143 months (95% CI: 60.143–69.601). Tumour site, patient age, stage of disease and treatment modality had a statistically significant hazardous effect on the overall and disease-free survival rates. The significant influence of age, site of tumour, stage of disease and modality of treatment required based on the clinic-pathologic risk factors on prognosis emphasizes the importance of early diagnosis through regular screening and early treatment which can be ensured with early referral, high clinical suspicion and awareness at the point of primary/secondary care. Keywords Disease-free survival . Overall survival . Oral squamous cell cancers
Introduction Oral cancer is the most common single site cancer in males and one among the most frequent sites (fifth in sequence) of cancer in females in Southeast Asia. 2018 reported 354,864 new cases of OSCC and 177,384 deaths worldwide (age-standardized rate of 2.8 per lakh population). [1] India has onethird of the global load of OSCC [2] and has contributed to 30% of global OSCC mortality (1,19,992 new cases and 72,616 deaths) in 2018 [3] having a difference in incidence between males (11.3%) and females (4.3%). Interestingly, Areca nut exposure affects the incidence in India by * Sourabha Kumar Patro [email protected] 1
Department of Otolaryngology and Head and Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
increasing the incidence in males and decreasing in females. [4] Squamous cancers predominate (90%) [5] and affect the overall prognosis. Prolongation of survival along with maintenance for quality of life (QOL) is target treatment outcome for OSCC. [6] NCCN (National comprehensive cancer network) gi
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