Symptom burden and treatment perception in patients with atrial fibrillation, with and without a family history of atria
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ORIGINAL ARTICLE
Symptom burden and treatment perception in patients with atrial fibrillation, with and without a family history of atrial fibrillation Taishi Fujisawa1 · Takehiro Kimura1 · Shun Kohsaka1 · Nobuhiro Ikemura1 · Yoshinori Katsumata1 · Hiroshi Miyama1 · Kazuaki Nakajima1 · Takahiko Nishiyama1 · Yoshiyasu Aizawa1 · Hideaki Kanki2 · Keiichi Nagami3 · Keiichi Fukuda1 · Seiji Takatsuki1 Received: 22 February 2020 / Accepted: 28 August 2020 © Springer Japan KK, part of Springer Nature 2020
Abstract Atrial fibrillation (AF) is known to aggregate within family and might be associated with a lower quality-of-life (QoL). We evaluated the association between a family history (FHx) of AF and patient-reported symptom burden and perception towards treatment. We performed a retrospective analysis in a cohort of 1285 newly diagnosed patients with AF. Patients completed the atrial fibrillation effect on quality of life (AFEQT) questionnaire at the time of registration and at the 1-year follow-up. Patients who had a first-degree relative with AF were classified into the FHx group. Baseline characteristics and AFEQT scores were compared between groups, and a multivariate analysis was used to evaluate the independent association between FHx and QoL. Overall, 15.9% of patients (n = 204) had a positive AF FHx. Compared to the non-FHx group, the FHx group had an earlier onset of AF (60.2 ± 12.0 years vs. 64.5 ± 12.1 years; P
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