Synthesis, Characterization, and Antibacterial Activity of Cd(II) Complexes with 3-/4-Fluorobenzoates and 3-Hydroxypirid
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OORDINATION COMPOUNDS
Synthesis, Characterization, and Antibacterial Activity of Cd(II) Complexes with 3-/4-Fluorobenzoates and 3-Hydroxypiridine as Co-Ligands Mustafa Sertçelika, * and Murat Durmanb a
Kafkas University, Department of Chemical Engineering, Faculty of Engineering and Architecture, Kars, 36100 Turkey b Kafkas University, Institute of Science, Kars, 36100 Turkey *e-mail: [email protected] Received January 13, 2020; revised February 10, 2020; accepted March 3, 2020
Abstract—In this study, two new complexes of Cd(II) 4-fluorobenzoate (4-FB)/3-fluorobenzoate (3-FB) with 3-hydroxypyridine (3-HPY) have been synthesized and structural characterizations have been performed by using elemental analysis, FT-IR spectroscopy, and single-crystal X-ray diffraction methods. In both complexes, the metal atom is chelated by two carboxylate groups from two 4- or 3-fluorobenzoate anions and coordinated by two 3-hydroxypyridine (HPY) molecules. In both complexes, an oxygen atom of carboxylate from the adjacent anion bridges to the Cd atom, completing the distorted seven-coordination geometry. The only difference between complexes is the positions of fluorine atoms in fluorobenzoic acids (4-fluorobenzoic acid (complex 1) and 3-fluorobenzoic acid (complex 2)). Antibacterial resistance of two new complexes to some bacteria has been investigated. Keywords: cadmium(II) complex, 4-fluorobenzoic acid, 3-fluorobenzoic acid, 3-hydroxypyridine, antibacterial, X-ray diffraction DOI: 10.1134/S0036023620090168
INTRODUCTION In recent years, the synthesis of new complexes with striking properties that can be used in various application areas has gained importance. These complexes are composed of metal atom/atoms at the center of symmetry and anions or molecules attached to the metal atom. These complexes stand out both with the variety of their structure and with their physical, chemical and biological properties. The structure and application-oriented properties of these compounds, which are part of material chemistry, are influenced by metal cations, ligands, and intra- and intermolecular interactions [1–7]. Carboxylic acids and ligands containing N-, O-, and S-donor atoms in their structure have many biological activities such as anti-inflammatory, antibacterial, antitumor, and antifungal [8–11]. Recent studies on antimicrobial activity of non-steroidal anti-inflammatory drugs have shown the increased antimicrobial activity of transition metals complexes with various carboxylic acid and nitrogen-containing ligands [12]. Therefore, it is very important to learn about the structure and binding relationships of complexes in the preparation of effective antimicrobial species [12]. Heterocyclic compounds are known to play an
important role in many biological systems, as components of various vitamins and drugs [13–15]. Antibiotics are the basic life-saving drugs that revolutionized the pharmaceutical world with the discovery of penicillin in 1928. Recently, bacterial infections have caused deadly diseases and widespread outbr
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