Synthesis of nanostructured mesoporous silica-coated magnetic nuclei with polyelectrolyte layers for tetracycline hydroc
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ORIGINAL ARTICLE
Synthesis of nanostructured mesoporous silica‑coated magnetic nuclei with polyelectrolyte layers for tetracycline hydrochloride control release Alex Carvalho Alavarse1,3 · Carlos Eduardo de Castro1,3 · Luana dos Santos Andrade2 · Fabio Furlan Ferreira1,3 · Jean Jacques Bonvent1,3 Received: 11 April 2020 / Accepted: 8 June 2020 © King Abdulaziz City for Science and Technology 2020
Abstract Colloidal drug delivery systems are one of the most promising tools for the treatment of several diseases. We present a synthesis route based on four steps involving mesoporous silica-coated magnetite nanoparticles (MNPs) capped by polyelectrolyte (PE) assembling. The morphology and physical properties of the different components of the system were investigated. The magnetite phase of the iron oxide nanoparticles was identified by X-ray diffraction before their incorporation into the mesoporous silica matrix by a sol–gel process. A MCM-41-like organized hexagonal mesoporous (≈4.2 nm) structure was achieved, as ensured by the αS-plot model. Polyethylenimine PEI and sodium alginate (ALG) PE layer-by-layer capping were successfully performed by simple successive dispersions of nanoparticles in the PE solution bath. TEM images confirmed a well-organized structure, as also supported by DLS and XPS analyses, which present an increase in diameter size and distinct chemical surface composition after each step of the synthesis. The two successive coatings of the MNPs induced a significative decrease of the magnetic susceptibility but kept sufficient intensity for drug delivery assisted by an external magnetic field. To validate the system as drug delivery, in vitro tetracycline hydrochloride (TCH) loading and release studies were performed in PBS solution for 48 h. It was found that the TCH-loaded uncapped mesoporous silica NPs released more than 90% of TCH after 48 h. Meanwhile, when capped by the PEs, only 30% of the total drug amount was released, due to a hindrance of the drug diffusion by the PE layer. The present work suggests that the combination of the low cost and non-toxic hybrid system proposed has potential use in nanomedicine as a drug delivery vehicle. Keywords Nanomedicine · Magnetite nanoparticles · Mesoporous silica nanoparticles · Polyelectrolytes · Drug delivery
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13204-020-01482-z) contains supplementary material, which is available to authorized users. * Alex Carvalho Alavarse [email protected] 1
Center for Natural and Human Sciences (CCNH), Federal University of ABC, Avenida dos Estados, 5001, Santo André, SP CEP: 09210‑580, Brazil
2
Center for Engineering, Modeling and Social Sciences (CECS), Federal University of ABC, Avenida dos Estados, 5001, Santo André, SP CEP: 09210‑580, Brazil
3
NANOMED, Nanomedicine Strategic Unit, Federal University of ABC, Avenida dos Estados, 5001, Santo André, SP CEP: 09210‑580, Brazil
It is a consensus that nanomedicine can offer man
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