Synthetic Immunology
This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunol
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Synthetic Immunology
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Takeshi Watanabe • Yousuke Takahama Editors
Synthetic Immunology
Editors Takeshi Watanabe Kitano Hospital Kita-ku, Osaka Japan
Yousuke Takahama Division of Experimental Immunology University of Tokushima Tokushima Japan
ISBN 978-4-431-56025-8 ISBN 978-4-431-56027-2 DOI 10.1007/978-4-431-56027-2
(eBook)
Library of Congress Control Number: 2016939272 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK
Preface for Synthetic Immunology
Immunology has developed rapidly over the last 50 years through the incorporation of new technologies and concepts in cell and molecular biology, genetics, genomics, and proteomics. This progress is the result of works by many scientists all over the world. Currently, immunological research has accumulated detailed knowledge on various mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of the immune system remain unknown. Synthetic biology is an emerging research field that uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we may now begin adapting the concepts of synthetic biology to immunology. With this in mind, we have experimentally started Synthetic Immunology Workshop in 2010 and have organized four meetings, including three international meetings, by now. An immune response is a spatiotemporal phenomenon occurring at a given time and at a
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