Systems Biology in Cancer Research and Drug Discovery
Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to de
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Asfar S. Azmi Editor
Systems Biology in Cancer Research and Drug Discovery
Editor Asfar S. Azmi Karmanos Cancer Institute Wayne State University Detroit, MI, USA
ISBN 978-94-007-4818-7 ISBN 978-94-007-4819-4 (eBook) DOI 10.1007/978-94-007-4819-4 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012949161 © Springer Science+Business Media Dordrecht 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to the noted social activist, the late Muqbil Mohammad Maqbool, who fought a strong-willed battle with cancer and to others who have fought and continue to fight the same battle, waiting patiently for these technologies to reach them.
Preface
Cancer is a global problem and apart from modest improvements in diagnostics, the last 60 years has witnessed no major breakthrough in eliminating most types of malignancies. It is quite unfortunate and frustrating to witness simultaneous increase in incidence and mortality rates as well as drug attrition. Part of the problems lies in our traditional molecular biology approach that applies reductionism to investigate a disease harboring uncountable variables. In order to make advancements in our understanding of cancer and to improve its management, there has to be a
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