Drug Discovery in Pancreatic Cancer Models and Techniques

Over the past two decades, tremendous advances have been made in the field of cancer drug discovery, particularly in the area of molecular and genetic models and technologies, many of which have been or are beginning to be applied to the drug discovery pr

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Haiyong Han · Paul Grippo Editors

Drug Discovery in Pancreatic Cancer Models and Techniques

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Editors Haiyong Han, Ph.D. Clinical Translational Research Division Translational Genomics Research Institute 445 N. Fifth Street Phoenix, AZ 85004, USA [email protected]

Paul Grippo, Ph.D. Department of Surgery Feinberg School of Medicine R.H. Lurie Comprehensive Cancer Center Northwestern University Chicago, IL 60611, USA [email protected]

ISBN 978-1-4419-1159-9     e-ISBN 978-1-4419-1160-5 DOI 10.1007/978-1-4419-1160-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010920006 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

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Foreword

Everyone picking up this book will be aware of what a devastating disease pancreatic cancer is. And probably everyone picking up this book wants to make a difference in the fight against that disease. This book was designed by Drs. Han and Grippo for those who want to make a difference. And the book clearly hits the mark. The contributing authors are extremely accomplished investigators who are sharing their state-of-the-art investigative knowledge on (1) molecular, proteomic, and bioinformatic techniques; (2) in vitro and in vivo systems (already established and new highly innovative models); and (3) new methods for clinical investigation. There is useful information for the beginning as well as for the accomplished investigator. The tables summarizing available cell lines, and available inhibitors and on special techniques are incredibly valuable. In addition to discussions of the more routine approaches to studying pancreatic cancer, the investigator is treated to insights on “cutting edge” approaches to studying the disease. At the time of the writing of this book, pancreatic cancer is the fourth leading cause of death from cancer in the US. Worldwide more than 200,000 people will die e