Systems Biology in Drug Discovery and Development Methods and Protoc
Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and D
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Systems Biology in Drug Discovery and Development Methods and Protocols
Edited by
Qing Yan PharmTao, Santa Clara, CA, USA
Editor Qing Yan PharmTao Santa Clara, CA USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-799-0 e-ISBN 978-1-60761-800-3 DOI 10.1007/978-1-60761-800-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010934107 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: See Figure 1 of Chapter 13 for more information. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Currently, the drug discovery industry has reached the bottleneck. Adverse drug reactions (ADRs) are one of the leading causes of death and illness in the US. In the mean time, although the industry is spending a tremendous amount of money and time, high-profile drug withdrawals are increasing, with fewer FDA approvals of new drugs. The “one-drugfits-all” model has not been successful. There is an urgent need to change the current drug discovery and development process that has high cost, low efficacy, and high ADRs. It is necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. Systems biology emerged with the realization that genes, molecules, tissues, and organs do not work alone but interact with each other in a whole system. Combined with pharmacogenomics studies, systems biology would provide a holistic and thorough understanding of health and medicine. Such understanding would change the emphasis of medicine from diseases to humans and enable the transformation from disease treatment to prevention and health promotion. T
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