Antibiotic Pharmacodynamics
This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situ
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John C. Rotschafer David R. Andes Keith A. Rodvold Editors
Antibiotic Pharmacodynamics
METHODS
IN
PHARMACOLOGY
AND
Series Editor Y. James Kang School of Medicine University of Louisville Prospect, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
TOXICOLOGY
Antibiotic Pharmacodynamics Edited by
John C. Rotschafer Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA
David R. Andes Division of Infectious Diseases, University of Wisconsin, Madison, WI, USA
Keith A. Rodvold Colleges of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, IL, USA
Editors John C. Rotschafer Department of Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota Minneapolis, MN, USA
David R. Andes Division of Infectious Diseases University of Wisconsin Madison, WI, USA
Keith A. Rodvold Colleges of Pharmacy and Medicine University of Illinois at Chicago Chicago, IL, USA
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-3321-1 ISBN 978-1-4939-3323-5 (eBook) DOI 10.1007/978-1-4939-3323-5 Library of Congress Control Number: 2016930313 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface The discovery of antibiotics is often considered one of man’s greatest achievements, but often the clinical and microbiologic outcome depends upon the skill of the clinician directing therapy. Over the last 30 years, two new sciences, pharmacokinetics and pharmacodynamics, have increased our understanding of antibiotic behavior in the human host and how these agents interact with bacteria. In vitro and In vivo pharmacodynamic modeling characterizes antibiotic performa
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