Targeting Oral Cancer
This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-re
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Targeting Oral Cancer
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Targeting Oral Cancer
Andrew M. Fribley Editor
Targeting Oral Cancer
Editor Andrew M. Fribley School of Medicine Wayne State University Detroit, MI USA
ISBN 978-3-319-27645-8 ISBN 978-3-319-27647-2 DOI 10.1007/978-3-319-27647-2
(eBook)
Library of Congress Control Number: 2016933453 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
Part I
1
2
3
4
Assessing the Changing Oral and Pharyngeal Cancer Demographic in the United States. . . . . . . . . . . . . . . . . Andrew S. Holpuch and Susan R. Mallery
3
The Emerging Role of HPV in Head and Neck Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Thomas E. Carey
21
Oral Cancer: Location, Staging, Surgical Management, and Outcomes. . . . . . . . . . . . . . . . . . . . . . . . . . . . Michael Z. Chen, Robert H. Mathog, Andrew M. Fribley, and George H. Yoo Chemotherapy in Head and Neck Squamous Cell Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Daniela M. Burchhardt and Ammar Sukari
Part II 5
6
7
The Dynamic Epidemiology of Head and Neck Cancers and Current Treatment Modalities
37
53
HNSCC: Molecular Progression, Biomarkers and Stem Cells
Molecular Signaling in Oral Cancer Invasion and Metastasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Insoon Chang, Aasia O. Rehman, and Cun-Yu Wang
71
Cancer Stem Cells in the Biology and Treatment of Head and Neck Squamous Cell Carcinoma . . . . . . . . . . . . . Hong S. Kim, April Adams, and Jacques E. Nör
101
HNSCC Biomarkers Derived from Key Processes of Cancerogenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Martina Raudenska, Jaromir Gumulec, Andre
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