Tau Biology
This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly l
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Akihiko Takashima Benjamin Wolozin Luc Buee Editors
Tau Biology
Advances in Experimental Medicine and Biology Volume 1184 Series Editors Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Nima Rezaei, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Akihiko Takashima • Benjamin Wolozin Luc Buee Editors
Tau Biology
Editors Akihiko Takashima Department of Life Sciences Gakushuin University Tokyo, Japan Luc Buee University of Lille, INSERM, CHU-Lille, Alzheimer & Tauopathies, LabEx DISTALZ Lille, France
Benjamin Wolozin Department of Pharmacology and Experimental Therapeutics Boston University School of Medicine Boston, MA, USA Department of Neurology Boston University School of Medicine
Boston, MA, USA Program in Neuroscience Boston University School of Medicine
Boston, MA, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-32-9357-1 ISBN 978-981-32-9358-8 (eBook) https://doi.org/10.1007/978-981-32-9358-8 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
The isolation of tau protein as a heat-stable protein from the microtubule fraction of porcine brain was first reported in PNAS in 1975. The protein was shown to be essential for microtubule assembly, and most early work on tau were done in the context of microtubule assembly and the microtubule network. In 1986, several
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