Technological Systems in the Bio Industries An International Study

Technological Systems in the Bio Industries: An International Study represents a comprehensive, interdisciplinary, and systematic effort to understand the nature and role of technological change in a rapidly evolving arena of economic activity that can be

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AN INTERNATIONAL STUDY

Economics of Science, Technology and Innovation VOLUME 26

Series Editors Cristiano Antonelli, University of Torino, Italy Bo Carlsson, Case Western Reserve University, USA.

Editorial Board: Steven Klepper, Carnegie Mellon University, USA. Richard Langlois, University ofConnecticut, USA. lS. Metcalfe, University ofManchester, UK. David Mowery, University ofCalifornia, Berkeley, USA. Pascal Petit, CEPREMAP, France Luc Soete, Maastricht University, The Netherlands

The titles published in this series are listed at the end ofthis volume.

Economics of Science, Technology and Innovation

TECHNOLOGICAL SYSTEMS IN THE BIO INDUSTRIES ANINTERNATIONALSTUDY

edited by

Do Carlsson Case Western University

SPRINGER SCIENCE+BUSINESS MEDIA, LLC

Library of Congress Cataloging-in-Publication Data Technological systems in the bio industries : an international study / edited by Bo Carlsson. p. cm. - (Economics of Science, technology, and innovation ; 26) Includes bibliographical references and index. TSBN 978-1-4613-5302-7 ISBN 978-1-4615-0915-8 (eBook) DOI 10.1007/978-1-4615-0915-8 1. Medical innovations-Cross-cultural studies. 2. Biotechnology-Technological innovations. 3. Medical technology-Case studies. R855.3 .T54 2001 610/ .28-dc21

2001057979

Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint of the hardcover 1st edition 2002 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permis sion of the publisher, Springer Science+Business Media, LLC

Printed on acid-free paper.

TABLE OF CONTENTS Preface Bo Carlsson List of Contributors List of Tables List of Figures

vii

ix Xl

xv

Introduction Bo Carlsson and Rikard Stankiewicz 2

3

4 5

6

7

8

The Analytical Approach and Methodology Bo Carlsson, Magnus Holmen, Staffan Jacobsson, Annika Rickne, and Rikard Stankiewicz

9

The Cognitive Dynamics of Biotechnology and the Evolution of Its Technological Systems Rikard Stankiewicz

35

The Biomedical Clusters in Ohio and Sweden: An Overview Bo Carlsson and Pontus Braunerhjelm

53

Micro-Level Analysis of Firms in the Biomedical Clusters in Ohio and Sweden Dilek Cetindamar and Jens Laage-Hellman

81

The Support Structure of the Biomedical Clusters: Research, Intermediary, and Financial Organizations Pontus Braunerhjelm, Dilek Cetindamar, and Dan Johansson

123

Regional Characteristics and Performance: Evidence from Biomaterials Firms Annika Rickne

145

Titanium Implants: A Competence Bloc Comparison of a Swedish Firm and an Ohio Firm Ann-Charlotte Fridh

187

VI

9

10

11

12

The Health Care Competence Bloc: On the Integration of Biotechnology, Pharmaceuticals and Medical Technologies with Hospital Care and Health Insurance Gunnar Eliasson

217

A Competence Bloc Analysis of The Economic Potential of Biotechnology in Agriculture and Food Production