Temporal bone carcinoma: testing the prognostic value of a novel clinical and histological scoring system
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OTOLOGY
Temporal bone carcinoma: testing the prognostic value of a novel clinical and histological scoring system Leonardo Franz1 · Elisabetta Zanoletti1 · Sebastiano Franchella1,2 · Diego Cazzador1,3 · Niccolò Favaretto1 · Leonardo Calvanese1 · Antonio Mazzoni1 · Piero Nicolai1 · Gino Marioni1 Received: 7 August 2020 / Accepted: 10 November 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Our group recently proposed the novel Padova prognostic scoring system for temporal bone carcinoma (TBSCC) that considers: the revised Pittsburgh staging system; radiological dura mater involvement; non-anterior spread (medial, inferior or posterior into the temporal bone and skull base) of T4 tumors; and histological grade. The aim of the present study was to validate this prognostic TBSCC scoring system in a case series selected from the literature. Methods A search was run to identify studies on TBSCC reporting the variables included in our score for each patient. Then our system was applied to the data extracted. Results Only two published investigations reported all the clinical and pathological data required for our scoring system. In one series from the Gruppo Otologico in Piacenza (Italy), a significantly higher recurrence rate (p = 0.008), shorter diseasefree survival (DFS) (p = 0.001), higher disease-specific mortality (DSM) (p = 0.006), and shorter disease-specific survival (DSS) (p = 0.004) were associated with scores ≥ 5. Receiver operating curve (ROC) analysis showed an AUC of 0.804 for TBSCC recurrence, and 0.832 for DSM. In a series from Kyushu University Hospital (Japan), a significantly higher DSM (p = 0.018) and shorter DSS (p = 0.021) were associated with scores ≥ 5. ROC analysis showed an AUC of 0.812 for tumor relapse and 0.790 for DSM. Conclusion Our TBSCC Padova scoring system confirmed its validity when applied to the only two international TBSCC series providing the required data. These preliminary results need to be confirmed in a multi-center prospective setting. Keywords Temporal bone · Ear · Squamous cell carcinoma · Prognostic score · External validation · TBSCC Padova scoring system
Introduction
Leonardo Franz and Elisabetta Zanoletti contributed equally to the manuscript’s preparation. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00405-020-06489-4) contains supplementary material, which is available to authorized users. * Gino Marioni [email protected] 1
Department of Neuroscience DNS, Otolaryngology Section, Padova University, Via Giustiniani 2, 35128 Padova, Italy
2
Department of Women’s and Children’s Health, University of Padova, Padova, Italy
3
Department of Neuroscience DNS, Section of Human Anatomy, Padova University, Padova, Italy
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