Tetravalent Platinum Complexes: Synthesis, Structure, and Antimicrobial Activity
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avalent Platinum Complexes: Synthesis, Structure, and Antimicrobial Activity A. R. Tkachevaa,*, V. V. Sharutina, O. K. Sharutinaa, N. M. Shlepotinab, О. L. Kolesnikovb, Yu. S. Shishkovab, and М. V. Peshikovab a South
b South
Ural State University (National Research University), Chelyabinsk, 454080 Russia Ural State Medical University of the Ministry of Healthcare of the Russian Federation, Chelyabinsk, 454092 Russia *e-mail: [email protected] Received November 5, 2019; revised November 5, 2019; accepted November 7, 2019
Abstract—The complexes [(C2H5)2NH2]2[PtCl6], [(C2H5)4N]2[PtCl6], and [(CH3)3NH]2[PtCl6] were prepared by the reaction of hexachloroplatinic acid with organylammonium chlorides in acetonitrile. Structure of these compounds was determined by X-ray analysis and infrared spectroscopy. The synthesized crystals consist of tetrahedral organylammonium cations and hexachloroplatinate octahedral anions. The antimicrobial activity of the synthesized complexes against the Escherichia coli strain M-17 was studied. Keywords: diethylammonium chloride, tetraethylammonium chloride, hexachloroplatinic acid, antimicrobial activity, Escherichia coli
DOI: 10.1134/S1070363220040155 Platinum coordination compounds and its derivatives are important chemotherapy drugs used to treat various types of cancer pathology. Platinum-based compounds have a potential advantage over other small molecules [1–3]. Amino groups in platinum complexes with polyamine ligands are capable of forming hydrogen bonds with DNA atoms [4, 5]. Platinum and palladium complexes with Schiff bases containing (N, O, S) donor atoms are bioactive, including anticancer, antifungal, and antibacterial activities [6–8]. The complex [PtL2]Cl2, where L is 2-methoxy-6({2-(4-[trifluoromethyl]pyrimidin-2-yl)hydrazono}methyl)phenol, in vitro has proven itself as an effective antimicrobial agent against Escherichia coli, as an antifungal agent against Candida albicans, and also has demonstrated a cytotoxic effect on tumor cell lines [9]. Platinum(II) complexes with ligands containing pyrazole and quinoline residues showed antibacterial properties in relation to the cultures of gram-positive and gramnegative bacteria, including E. coli [10]. The antitumor and antimicrobial effects of platinum compounds are explained by inhibition of the DNA, RNA, and protein syntheses [11], the formation of cross-links between DNA chains, and the fixation of one of its chains by the preferential drug binding with purine nitrogenous 655
bases (e.g., cisplatin can bind to DNA linker regions). In addition, platinum can form one valent bond with DNA and another, with amino and hydroxyl groups of a protein molecule [12–14]. Infectious pathology is a pressing problem in oncology [15–17], and the presence of anticancer and antimicrobial activity of platinum complexes can be used in clinical practice. In view of the significant spread of resistant strains and the formation of bacterial biofilms, continuous monitoring of resistance and search for alternative antimicrobial agents are necessary to
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