Biogenic synthesis, antioxidant and antimicrobial activity of silver and manganese dioxide nanoparticles using Cussonia
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ORIGINAL PAPER
Biogenic synthesis, antioxidant and antimicrobial activity of silver and manganese dioxide nanoparticles using Cussonia zuluensis Strey Nomfundo T. Mahlangeni1 · Judie Magura1 · Roshila Moodley1 · Himansu Baijnath2 · Hafizah Chenia2 Received: 24 January 2020 / Accepted: 4 June 2020 © Institute of Chemistry, Slovak Academy of Sciences 2020
Abstract Synthesis of nanoparticles using naturally occurring biomolecules has become the preferred method due to increased concerns over environmental degradation. In this study, the biosynthesis of manganese dioxide nanoparticles (MnO2NPs) and silver nanoparticles (AgNPs) using extracts and the biomolecule, aralia cerebroside, isolated from the medicinal plant species, Cussonia zuluensis Strey, was investigated. The size and morphology of nanoparticles observed using microscopic techniques indicated an average particle size of 7.43 nm (spherical and polydispersed) for AgNPs and a layer of thin film surrounding the particles, confirming the capping by biomolecules. AgNPs exhibited better antibacterial activity than M nO2NPs and were most active against Escherichia coli and Enterococcus faecalis. MnO2NPs presented as ultrathin nanoflakes with grainy morphology ranging from 11 to 29 nm when capped with biomolecules from the extract, and presented as nanospheres surrounded by nanosheets ranging from 6.99 to 16.57 nm when capped with aralia cerebroside. The radical scavenging activity was found to be MnO2NPs (extract) > MnO2NPs (cerebroside) > AgNPs (extract) > extract > cerebroside, and the ferric reducing antioxidant power was found to be cerebroside > extract > MnO2NPs (cerebroside) > MnO2NPs (extract) > AgNPs (extract). MnO2NPs exhibited better antioxidant activity than AgNPs with size and morphology of nanoparticles being influenced by the capping agent, which, in turn, influenced antioxidant activity as seen with M nO2NPs. This study confirms the significance of the metal or metal oxide core and capping biomolecules for targeted therapeutic activity of nanoparticles using the plant-mediated synthesis route. Keywords Aralia cerebroside · Silver nanoparticles · Radical scavenging activity · Escherichia coli · Enterococcus faecalis
Introduction The synthesis of nanoparticles using biological materials has been proposed to be a non-toxic and eco-friendly alternative to physical and chemical approaches (Parveen et al. 2016; Nasrollahzadeh et al. 2019). The biological materials including DNA, proteins, peptides, bacteria, fungus and plants have been successfully exploited for the synthesis of Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11696-020-01244-9) contains supplementary material, which is available to authorized users. * Roshila Moodley [email protected] 1
School of Chemistry and Physics, University of KwaZuluNatal, Durban 4000, South Africa
School of Life Sciences, University of KwaZulu-Natal, Durban 4000, South Africa
2
nanoparticles (Deljou and Goudarzi 2016; Leng et al. 2016;
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