Th9 Cells Methods and Protocols
This volume presents comprehensive laboratory protocols that have been used to generate Th9 cells, both in vitro and in vivo. The techniques described in Th9 Cells: Methods and Protocols study the role of Th9 cells in different inflammatory disease models
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Ritobrata Goswami Editor
Th9 Cells Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Th9 Cells Methods and Protocols
Edited by
Ritobrata Goswami School of Bio Science, Sir JC Bose Laboratory Complex, Indian Institute of Technology, Kharagpur, West Bengal, India
Editor Ritobrata Goswami School of Bio Science Sir JC Bose Laboratory Complex Indian Institute of Technology Kharagpur, West Bengal, India
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6876-3 ISBN 978-1-4939-6877-0 (eBook) DOI 10.1007/978-1-4939-6877-0 Library of Congress Control Number: 2017937939 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface T helper cells that play an important role in adaptive immune response have a new member, Th9 cells. Th9 cells secrete IL-9, a pleiotropic cytokine having biological effects on distinct cell types. It has been more than 25 years since the cloning of IL-9. IL-9 can be produced by various cell types including long-term T cell lines and mast cells; however, T helper cells produce copious amounts of IL-9 in the presence of IL-4 and TGF-β. This discovery has propelled the study of Th9 cells with enthusiasm. Over the last eight years, several studies have tried to optimize the conditions for the production of Th9 cells, transcriptional regulation of Th9 cells, and the in vivo function of Th9 cells. One of the goals of this book is to present com
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