The Antagonistic Effects of Selenium Yeast (SeY) on Cadmium-Induced Inflammatory Factors and the Heat Shock Protein Expr
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The Antagonistic Effects of Selenium Yeast (SeY) on Cadmium-Induced Inflammatory Factors and the Heat Shock Protein Expression Levels in Chicken Livers Yong Wang 1 & Junfeng Liu 1 & Rong Chen 1 & Meng Qi 1 & Dayong Tao 1
&
Shiwen Xu 1
Received: 6 November 2019 / Accepted: 7 January 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Cadmium (Cd) is a ubiquitous toxic heavy metal in the natural environment that can cause multiple organ damage to the bodies of animals and humans. Selenium yeast (SeY) is a kind of organic selenium (Se) that has a very strong function against Cd-induced injury to tissues or organs. The aim of the current study was to investigate the roles of inflammatory factors and heat shock proteins (HSPs) in inflammatory injury triggered by Cd and to analyze the protective effects of SeY on Cd-induced damnification in the livers of chickens. Two hundred 120-day-old layers were randomly divided into four groups and raised on a conventional diet, or with Se (0.5 mg/kg SeY), Cd (150 mg/kg CdCl2), or Se + Cd (0.5 mg/kg SeYand 150 mg/kg CdCl2) in their basic diets for 120 days. Then, the liver histopathology, production of nitric oxide (NO), activity of inducible NO synthase (iNOS), and mRNA and protein expression levels of inflammatory factors (iNOS, NF-κB, TNF-α, and PTGE) and heat shock proteins (HSPs 27, 40, 60, 70, and 90) were examined. The results showed that exposure to Cd obviously increased Cd accumulation, NO production, iNOS activity, inflammatory factor, and HSP mRNA and protein expression levels and further caused an inflammatory response. Supplementation with SeY had an antagonistic effect on Cd-induced inflammatory injury in chicken livers. Thus, the present study suggests that SeY can be taken as a potential therapeutic for Cd-induced liver inflammatory injury in chickens. Keywords Cadmium . Selenium yeast . Inflammatory factors . Heat shock proteins . Chicken liver
Introduction Cadmium (Cd), which mainly originates from the plastic, smelting, battery, pigment, metal mining, fossil fuel combustion, and fertilizer industries is a very common toxic heavy metal in the natural environment [1, 2]. According to previous reports, approximately 30,000 tons of Cd are introduced into the environment every year and cause serious environmental pollution. The large exposure of Cd in the environment causes a serious threat to humans and animals mainly by the take of contaminated food and water [3]. Thus, Cd pollution has Yong Wang and Junfeng Liu contributed equally to this work. All authors have read the manuscript and have agreed to submit the manuscript in its current form for consideration for publication in this journal. * Dayong Tao [email protected] 1
College of Animal Science, Tarim University, Alar 843300, Xinjiang Uygur Autonomous Region, China
received increasing attention [4]. The exposure of Cd also affects the health of wildlife, such as in wild snowshoe hares (Lepus americanus) near Yellowknife in the Northwest Territories of Canada, wild boar
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