The Biology of mRNA: Structure and Function

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right tim

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Marlene Oeffinger Daniel Zenklusen  Editors

The Biology of mRNA: Structure and Function

Advances in Experimental Medicine and Biology Volume 1203

Series Editors Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Nima Rezaei, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

More information about this series at http://www.springer.com/series/5584

Marlene Oeffinger • Daniel Zenklusen Editors

The Biology of mRNA: Structure and Function

Editors Marlene Oeffinger Systems biology (IRCM), Biochemistry and Molecular Medicine (UdeM), Experimental Medicine (McGill) Institut de recherches cliniques de Montréal (IRCM), Université de Montréal, McGill University Montreal, QC, Canada

Daniel Zenklusen Department of Biochemistry and Molecular Medicine Université de Montréal Montréal, QC, Canada

ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-31433-0 ISBN 978-3-030-31434-7 (eBook) https://doi.org/10.1007/978-3-030-31434-7 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Regulating gene expression is an essential task for every cellular system in which mRNA serves as the central messenger molecule of the gene expression pathway bridging the information stored in DNA and providing the template for protein synthesis. Yet, mRNA is far from a simple copy of genetic information, and the path from its making to serving in proteins synthesis is one of the most complex cellular processes, involving hundreds of fa