The Challenge of Highly Pathogenic Microorganisms Mechanisms of Viru
This book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, vir
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Avigdor Shafferman Arie Ordentlich Baruch Velan Editors
The Challenge of Highly Pathogenic Microorganisms Mechanisms of Virulence and Novel Medical Countermeasures
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Editors Avigdor Shafferman, Ph.D. Israel Institute for Biological Research 74100 Ness-Ziona Israel [email protected]
Arie Ordentlich, Ph.D. Israel Institute for Biological Research P.O. Box 19 74100 Ness-Ziona Israel [email protected]
Baruch Velan, Ph.D. Israel Institute for Biological Research P.O. Box 19 74100 Ness-Ziona Israel [email protected]
ISBN 978-90-481-9053-9 e-ISBN 978-90-481-9054-6 DOI 10.1007/978-90-481-9054-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010927323 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The OHOLO conferences are sponsored by the Israel Institute for Biological Research and take their name from the site of the first meeting on the shores of Lake Kinnereth. The purpose of these meetings is, as it was at their inception over 50 years ago, “to foster interdisciplinary communication between scientists in Israel, and to provide added stimulus by the participation of invited scientists from abroad”. The core of the organizers of the OHOLO conferences are scientists from the Israel Institute for Biological Research. From time to time a particular OHOLO conference cooperates with an international scientific organization. The present 46th OHOLO Conference marks the resumption of the OHOLO tradition after 8 years of interruption caused by events beyond our control. It is my belief that our uncompromising commitment to excellence in research and development in the various areas of science in Israel is essential to our survival in this troubled region. The OHOLO conference tradition is a reflection of this conviction. The present 46th OHOLO Conference entitled: The Challenge of Highly Pathogenic Microorganisms – Mechanisms of Virulence and Novel Medical Countermeasures intends to address the unique virulence features and hostpathogen interactions of microorganisms constituting emerging biothreat with emphasis on Y. pestis, B. anthracis, F. tularensis and Orthopox viruses. Accordingly we selected classical microbiological as well as genomic, proteomic & transcriptomic approaches towards developments of novel prophylactic and post-exposure treatment, as well as updated strategies of diagnostics and bioforensics. I wish to thank the members of the international Scientific Advisory committee: Elisabeth Carniel, Arthur Friedlander, Paul Keim, Johannes Löwer, Michèle Mock and
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