The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiogr
- PDF / 900,445 Bytes
- 17 Pages / 595.276 x 790.866 pts Page_size
- 90 Downloads / 187 Views
RESEARCH ARTICLE
Open Access
The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis Mukundan Attur1,2*† , Svetlana Krasnokutsky1†, Hua Zhou3†, Jonathan Samuels1, Gregory Chang4, Jenny Bencardino4,5, Pamela Rosenthal1, Leon Rybak3, Janet L. Huebner6, Virginia B. Kraus6 and Steven B. Abramson1
Abstract Objective: Predictive biomarkers of progression in knee osteoarthritis are sought to enable clinical trials of structure-modifying drugs. A peripheral blood leukocyte (PBL) inflammatory gene signature, MRI-based bone marrow lesions (BML) and meniscus extrusion scores, meniscal lesions, and osteophytes on X-ray each have been shown separately to predict radiographic joint space narrowing (JSN) in subjects with symptomatic knee osteoarthritis (SKOA). In these studies, we determined whether the combination of the PBL inflammatory gene expression and these imaging findings at baseline enhanced the prognostic value of either alone. Methods: PBL inflammatory gene expression (increased mRNA for IL-1β, TNFα, and COX-2), routine radiographs, and 3T knee MRI were assessed in two independent populations with SKOA: an NYU cohort and the Osteoarthritis Initiative (OAI). At baseline and 24 months, subjects underwent standardized fixed-flexion knee radiographs and knee MRI. Medial JSN (mJSN) was determined as the change in medial JSW. Progressors were defined by an mJSN cut-point (≥ 0.5 mm/24 months). Models were evaluated by odds ratios (OR) and area under the receiver operating characteristic curve (AUC). (Continued on next page)
* Correspondence: [email protected] † Mukundan Attur Svetlana Krasnokutsky Hua Zhou are co-first authors and contributed equally to work. 1 Department of Medicine, NYU Grossman School of Medicine, New York, NY, USA 2 Division of Rheumatology, Rheumatology Research laboratory, NYU Langone Orthopedic Hospital, 301 East 17th Street, Suite 1612, New York, NY 10003, USA Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zer
Data Loading...
